Black Tea Down Regulates Receptor Activity

Lol …u think Finasteride inhibits only dht? It has the capacity to change ur DNA itself.

Update: Seems the bowel movement thing was short lived, had to use the bathroom twice today already.

I started taking the black tea last week on Monday. Took it up till Friday. That day I noticed my stomach hurt for a little bit. Then over the weekend it seemed like my gut issues improved. I resumed taking it Monday and today Tuesday. Earlier this morning I felt my stomach hurting again for no reason. That might have been when I reverted back to having the gut issues.

I probably should’ve quit while I was ahead lol.

Edit - Now my back is hurting in addition my stomach. Add fatigue to it too. I fucked up trying this.

It was stronger than I thought it would be, although I should’ve known when I get the pressure in my head/brain fog.

Ending this experiment for now.

Update: Feel fine two days later off of it. No lasting effects

Hold it right there @lbv I’m getting the exact same symptoms, it seems. My back hurts too especially before or after having BMs, I never suspected the black tea may be the culprit :thinking:. I’m also getting like 2-3 (sometimes 4) BMs a day and from my experience, more BMs corroborates with brain fog. It may be the caffeine content as coffee also makes me go but not really sure. I’ll cut black tea for a few days and see how this goes.

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What’s BM?

Yea my back started hurting and stomach. The brain fog was awful for a few hours one day. I might try it again for a few days to see if I can go back to normal bowel movements cause it worked for 3 days.

Bowel movement. Funny how I like others suffer from constipation while others like you and doomed are shitting yourselves silly. Shit is so bizarre. Get the boba with the brown sugar this time and don’t make yourself worse please godspeed.

what

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Even if it doesn’t work, you got this going for you:

lol yea shit could go either way, literally lol

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Interesting, keep us updated.

Where on earth did you find that chart of DHT levels in feces?

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From this study which I posted here a long while ago that somehow flew under the radar: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962501/

In conclusion, the findings in the present study demonstrate that the GM in the cecum deglucuronidates high levels of glucuronidated DHT and T found in the small intestinal content. This results in remarkably high free levels of the potent androgen DHT in the distal intestinal content of healthy young mice of both sexes and men. We propose that treatments with probiotics or changes in the diet affecting the GM composition might modulate intestinal androgen metabolism and thereby affect the risk of androgen-related diseases mainly in the distal intestine, but potentially also at extraintestinal locations. Further studies are needed to evaluate the physiological and pathophysiological roles of the high levels of free DHT in the distal intestine.

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Could you please explain the graph? Does it mean the concentration of T & DHT are higher in feces than serum? I learned the hard way the frequent BMs are tied to worse symptoms. I’m still unsure what’s messing with my frequency and stool consistency. That said, I’m on Activia yogurt (contains Bifido lactis) and Culturelle (contains L. Rhamnosus GG) so they may also have something to do with this. I’ll stop both for now. I’ve cut the black tea already.

Intriguingly, I notice higher libido when I have less BMs and when ever I tend to be constipated.

Sure thing

Same here. The harder my poops are and less frequent I go poopie, the more libido.

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Exactly @Sawproblemo I observed that for a long time. The graph @Mercked shared may explain this happenstance. All active hormones (including T; E2 & DHT) in the circulation are deactivated, as part of their metabolism, by the liver and certain enzymes and are excreted from the body via feces and urination. For example, nearly all testosterone (unless it is continuously produced) would be gone from the body in less than about 50 minutes to 8 hours, being destroyed by degradative enzymes, such as by those in the liver. This is why having optimal SHBG level is critical because it binds most of the sex hormones so that they could last longer in the circulation but that’s for another topic.

The interesting part though, gut microbiome is able to restore some of the excreted hormones, through certain enzymes produced by bacteria, back into the circulation. I suspect loose and/or frequent stools may lead to less recycling efficiency causing lower serum levels and hence lower libido. Neurotransmitters such as dopamine and serotonin are also made in the gut from breaking down protein into individual amino acids, which are precursors to the said neurotransmitters.

The gut mediates countless bodily processes and when messy, everything falls apart.

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Thanks.

It’s surprising they didn’t include androstanediol and androstanediol-glucuronide in the study since it represents the lowest energy form of androgen (only chemically speaking) and has been quoted in literature as representative of the average sum of DHT in the body, in addition to having some estrogenic activity and acting as a DHT precursor in some tissues through oxidative activity of 3a-HSD/3a-HSOR enzymes. The relevance of androstandediol to this study would be conversion between it and DHT occurring in the gut, if at all.

.

Can you please post links describing this? I have a bad habit of collecting studies.

Likewise @Dubya_B :grin: I recall this was elucidated in great detail by renowned TRT doctor ( Dr. Marianco) on PeakTestosterone forum. That said, this NCBI citation explores the half-life of TT, FT, Bioavailable T, Albumin-Bound T, & SHBG-Bound T correlated with T injections in 14 healthy men. They used a special methodology to block T production from gonads and adrenals to estimating elimination time.

Synopsis:
"Slow-phase T half-lives were highest for SHBG-bound T (32 min) and total T (27 min) with the former exceeding that of free T (18 min), bioavailable T (14 min) and albumin-bound T (18 min)[ P < 0.001]. Collective outcomes indicate that (a) the rapid phase of T disappearance from point sampling in the circulation is not explained by T dose; (b) SHBG-bound T and total T kinetics are prolonged; and © the half-lives of bioavailable, albumin-bound and free T are short."

It’s a long read but provides a great insights.

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Thanks. That sounds brutal what they put those guys through.

You’re welcome. Yep it’s striking how some healthy individuals agree to go through this, voluntarily.

I drink 4-5 cups a day and it’s good for brain fog no other use

Have you tried eating a lot of watermelon, that might help you go right away.