I’ve read somewhere That Bifidus strands were supposed to make up 90% of the gut’s biome (if I remember correctly), Acidophilus 5% (they’re supposed to help Bifidus by making the guts more acid which kills and reduces competing bacteria) and 5% other strands including a little bit of E-coli which are beneficial…
From what I understand, the Acidophilus / Bifidus pair is primordial in maintaining a healthy guts balance.
I had a conversation with a guy on this forum saying that PFS sufferers don’t have Bifidus strands, nor E-coli which is really abnormal (if it’s true, and I can’t confirm). The conclusion to this discussion was that whatever caused our chemical imbalance also made our guts inhospitable to Bifidus and E-coli. We also concluded that if we don’t address this imbalance, taking Bifidus probiotic would not work as our guts are still inhospitable to them.
I also read many threads where they talk about guts imbalance and wanting to address it. I can’t remember anyone claiming being cured by taking probiotics only (some cases of autism or severe depression did get cured this way so it would not be so far fetched, but it’s not the case for PFS as far as I’m aware of)
I believe our disease is above all an epigenetic disease and I adhere to the theory that our silenced androgen receptors result in a state of polyglutamic toxicity. Aside from the symptoms we know (high Glutamate / low GABA being a prime example), this toxicity could be responsible for making our guts inhospitable to Bifidus.
I’ve been working with some degree of success IMO on repairing my epigenome using diet, exercise and some other tricks documented elsewhere on this forum.
I am now cultivating strands of Bifidus and Acidophilus in a jar using cucumbers or cabbage, and I’m eating some live bacteria everyday. I do take Bifidus probiotics capsules on top of that. I have no proof they die or stay alive. Those who know me know I’m not a get tested kind of guy. I judge by results, not by written words and numbers on a paper, no offense to those who do: you do you, I do me. My results so far is that mood is better and I have less stress, I wouldn’t call what I had anxiety at this point although I did have severe anxiety in the past (the kind I wanted to die to avoid).
I’ll keep at it. So far the diet has by far yielded the best results, exercise and trick as well as NAD+ boosters (NMN) and bifidus supplements seems to help, but not as clearly as the diet.
In my case, there seems to be a particular set of events and circumstances that can trigger stronger symptoms, or diminish them in their absence. In my case again, there appear to be psychological triggers or inhibitors that influence the severity of symptoms. Before anyone jump at my throat, I will point out that psychological stress is one of the causes of epigenetic changes, in some case enough to cause diseases very similar to ours. A girl whose mother in law was stressing her out so much developed the same kind of symptoms we have. A bad boss, a stressful “love” relationship etc… can all cause adverse epigenetic changes. At this point, it’s a theory for me, not an affirmation.
However, to test it out, I will try to avoid the recognized psychological triggers and see if it does something.
Bottom line: the disease is most certainly epigenetic, the epigenetic changes may have caused guts biome imbalances but it’s not clear if we can address those before addressing the epigenetic causes, which are undoubtedly chemical (fin or other) and quite possibly environmental although there’s not enough evidence to conclude environmental causes are factual.
Nonetheless, I’m working on those three aspects: my epigenome first, than my guts biome and my psychological state.
I’ll keep you guys posted on the results as they come.
I wish you all the best.