For those of you who wants to try reducing your estrogen dominance by
taking anti aromatase drugs please consider the following link.
ncbi.nlm.nih.gov/pubmed/15813607
clincancerres.aacrjournals.org/c … l/9/1/468S
As i am a believer that my problems consist not only an aging liver but
suspect that i have some kind of addrenal fatique (although i do not know
the severity) therefore it will also affect my throid function for sure.
It turn out that femara (letrozole) can supress your adrenal function
even further (even at .5 mg) here is some lines from the study
QUOTE:
Anastrozole data indicate that it has no impact on adrenal steroidogenesis at up to 10 times the clinically recommended dose, thus suggesting that this drug has little activity on other cytochrome P450 enzymes involved in steroid synthesis (40) . In one study in healthy postmenopausal women, basal and ACTH stimulation did not differ from baseline levels after 14 days of anastrozole at a 5- or 10-mg daily dose (40) . In another study, there was no change in the ACTH-stimulated response after 115 days on therapy (41) . Letrozole studies showed a decrease in basal and ACTH-stimulated cortisol synthesis. In one study, patients with advanced breast cancer showed a significant decrease in ACTH-stimulated aldosterone levels after 3 months of letrozole treatment (2.5 or 0.5 mg; Ref. 42 ).
Here is another from a different study
QUOTE:
Twenty-four patients met the study inclusion criteria. Six patients treated with androgen were analyzed separately. Low-dose ACTH stimulation tests were performed to ascertain the effect of letrozole on adrenal gland function. In patients not on androgen, bone age progression decelerated from 1.51+/-0.57 (deltabone age/deltachronological age) before treatment to 0.68+/-0.66 on therapy (mean duration 12.4 months; p <0.0005). Predicted adult height standard deviation scores (SDS) increased from -1.41+/-0.54 to -0.64+/-0.65 on treatment (p <0.0005). Similar results were noted in androgen-treated patients. Approximately one-fourth of patients displayed subnormal responsiveness to ACTH. In summary: 1) letrozole decelerates skeletal maturation, resulting in significant increases in predicted adult height, and 2) letrozole causes mild adrenal suppression.
And for those of you please be very careful abour AROMASIN (Exemestane) since it is an IRREVERSIBLE aromatase inactivator.
Anything that is permanent is very dangerous.
Hope this information helps
