I ordered a bottle of Novedex before noticing topics about it on this forum. It hasn’t arrived yet though. Investigated it a bit and got worried.
One of the active ingredients in Novedex seems to be 3, 17-keto-etiochol-triene. Wikipedia says about it the following:
"[i]1,4,6-Androstatrien-3,17-dione (ATD) is a potent irreversible aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue.[1] It is used to control estrogen synthesis.[2]
ATD is present in some over-the-counter bodybuilding supplements as well as Topical ATD solutions that work transdermally. While not banned, ATD may cause positive urinanalysis results leading to disqualification from competitive sports. ATD has many names in sports supplements including: 1,4,6 etiollochan-dione, 3, 17-keto-etiochol-triene, androst-1,4,6-triene-3,17-dione and many others. These all refer to CAS# 633-35-2.[/i]"
About irreversible aromatase inhibitors it says “Irreversible steroidal inhibitors such as exemestane form a permanent bond with the aromatase enzyme complex.”
About Exemestane (which shares similar pharmacological model of action than Novedex) it says: "[i]Exemestane (trade name Aromasin) is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. An aim in the treatment of hormone-receptor-positive patients in preventing recurrence is to lower estrogen levels that this breast cancer thrives on.
The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body’s estrogen is produced in the adrenal gland from the conversion of androgens into estrogen by the aromatase enzyme. Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as “suicide inhibition.” In other words, Exemestane, by being structurally similar to the target of the enzymes, permanently binds to those enzymes, thereby preventing them from ever completing their task of converting androgens into estrogens.
The estrogen suppression rate for exemestane varies from 85% for estradiol (E2) to 95% for estrone (E1).[/i]"
What does this mean? Do our bodies form new aromatase and the effects of aromatase-inhibitor vanish after a while when we quit taking the drug, or are there only limited amount of nonrenewable aromatase-receptors in body, meaning that by taking something that “binds irreversibly to the active site of the enzyme causing its inactivation” we expose ourselves with god-knows-what kind of permanent physiological and personality changes?