I think the best way to go about treating PFS is to target the areas which are most affected first, where AR levels are the highest. I think for a good portion of us that would be the Brain, the trouble is working out exactly what areas of the Brain that would be or what areas in the body in general. Another therapy which might be good could be TMS, I think any therapy which can target a specific area like PBMT, or a therapy which has a whole body effect would be quite good, I’ve often thought that HBO therapy might be good, but less than ideal as it doesn’t target a specific area. Also something which has helped dramatically with sleep, and have helped with symptoms are blue blocking glasses, they block blue light which allow for the release of melatonin.
Melatonin has been shown to increase sirt1 activity, sirt1 has ben shown to decrease AR levels. And the good thing is CSF levels of melatonin are higher than peripheral levels which suggests levels are much higher in the Brain/CNS, which would mean natural release of melatonin could have a positive effect on AR levels in the Brain. I have taken exogenous melatonin before and it made me worse, the reason I think this is the chase is in th original post (accumulates more in body that brain). https://pubmed.ncbi.nlm.nih.gov/28109165/
BlockquoteNumerous findings report a rise in activity, especially on SIRT1, in a diversity of cells and animal models after melatonin treatment.
BlockquoteSeveral studies have shown that levels of melatonin in CSF are much higher than those in the blood. Evidence indicates that melatonin originating from the pineal gland and melatonin synthesized by brain tissue both contribute to the high level of melatonin in CSF
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Also this study found melatonin ‘attenuates’ activity of the AR: https://pubmed.ncbi.nlm.nih.gov/11582594/
Blockquote. Despite this increase and maintenance of AR agonist binding capacity, the androgen-induced reporter gene activity and suppression of AR-mRNA were attenuated.
So what I’m saying is allowing for natural melatonin release at night by avoiding blue/bright light should help us. It does for me.