AR signaling silenced by DHT

[Costa]

ncbi.nlm.nih.gov/m/pubmed/23041672/

It mentions something about dht silencing AR signaling. Maybe has to do something with the return of dht after stopping fin.

[Dubya_B]

That’s interesting man.

Looks like they are actually saying DHT prevents ubiquitination (being “tagged” for destruction) and proteosome degradation (being “eaten” by a proteosome) of AR by supressing the molecule that moves it out of the nucleus and into the cytoplasm (NES).

Ubiquitination of GFP-AR or GFP-LBD was suppressed in the presence of dihydrotestosterone, which is known to suppress NES(AR) while inducing nuclear localization signal 2 in AR or LBD, suggesting that the export activity of NES(AR) is required for NES(AR)-mediated polyubiquitination

The Italian PFS study found absurdly high nuclear concentration of AR in some cells.

[BP7667]

Excellent find, helps to explain the brief recovery period many of us experience. I will give it a detailed read through when I have more time.