AR over expression

So is it the consensus on why we have PFS because of a over expression in our androgen receptor? So the idea behind that would be it’s pumping out too much testosterone and dht and estrogen raises to counteract it? And this would all be on a cellular level?

Hi @voice

When you have a chance, please have a read of Baylor’s research results.

If you’re interested I’d also check out @axolotl’s literature review. It’s a long read but provides an excellent overview of the scientific concepts and how AR overexpression provides a good explanation for the multi-systemic nature of PFS, along with some of the other key features including “the crash”.

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