Anyone get absolutely screwed by any pharma med?

Before PFS I was okay with anything… Corticosteroids etc. But now I get ruined by any drug, oddly only a specific few; here is my list:

.Cyclosporine; worsened my hEDS considerably - POTS, Joint cracking, skin fuckery, suicidal thoughts, hot flashes… Funny that this is the med that fucked me over, 1000000x times worse than what finasteride did. Ugh. I recently crashed again and the sides were like I went on fin again…

.Corticosteroids; Not as bad as cyclo but made me superrrrr dissociated. Like insane derealisation and suicidal thoughts for a couple of hours.

.Nicotine; Same sides as cyclosporine + corticosteroids… Gradually decline whilst on it; low e2 sides mostly, I remember being impotent for 4months straight, also took away my allergies.

Seems like anything that messes with my adrenals or immune system crashes me hard… I’ve tried herbs etc but nothing has fucked me over as much as the above.

Can anyone weigh in here? Seen a lot of people trying cyclo and it helping, odd that its not helping me.

Please search all the meds you mentioned here if they are metabolized by P450 enzymes. There is a theory that we are P450 enzymes deficient now after fin sides.

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It messes with androgen receptor and testosterone levels…quick Google shows monkeys with androgen receptor