Any new PDE-5 inhibitors soon to be released?

Just wondering if there are any new and improved PDE-5 inhibitors or other ED type drugs lined up to hit the market in the near future?

Also how long till viagra’s patent runs out?

India doesnt recognize pharmaceutical patents and have pharmaceutical manufactures with high quality standards, if you see what I mean… You shouldnt bother about the price of “original” pfizer viagra when cheap good quality generics are available…

im curious of how it would work on us - with or without a pde5
en.wikipedia.org/wiki/Pentoxifylline

note that it also can treat neuropathy (which some of us have) and reduce inflammation…

Avanafil will be released soon, supposed to be faster acting. But it just does the same thing as the others, gets bloodflow to the cock.

Zoraxel is more interesting since it’s supposed to work on dopamine and serotonin receptors and induce libido, but it’s about two-three years off if it even comes to fruition.

[quote=“Luckfax”]
Avanafil will be released soon, supposed to be faster acting. But it just does the same thing as the others, gets bloodflow to the cock.

Cool how soon are we talking, any idea?

Whats wrong with the current pde5i?

Something quicker acting would be really beneficial.

The way things are i have to be certain im going to get lucky, and therefore take one in advance, and at least an hour in advance. But if im not sure if im going to get lucky i dont want to pop a pill, only to have nothing eventuate. Waste of money and also rather not take any more pills than are absolutely necessary.
If there was something that worked in say 15 minutes, i could really wait till the last moment before taking one which would be ideal.

And of course anything with less side effects would be nice too, viagra gives u that racing heart beat and flushed face, but some people get worse reactions, plus theres talk about it affecting your eyes.

Here is an article from WebMD on possible treatments for ED in the works.
webmd.com/erectile-dysfunction/guide/future-treatments-ed

The article states that Uprima is available in Europe. Has anyone tried it?

Yeh i think Avanafil sounds quite promising. Nice that u can use it twice a day if need be and thats its faster acting. Im hanging for this to become available!

Also would be very interested to find out if anyone has had success with Uprima…

I wonder if we would gain tolerance to these as people report for the current ones.

Well at least if we have more pde-5s to cycle between hopefully there will be less of a build up of tolerance…

I agree. But why the tolerance…

It’s strange, isn’t it.

The body builds up a tolerance to just about everything ffs. I have to cycle cialis (2-3 days a week) which works effectively.

2-3 days a week is not bad… So basically you use it and then have to wait 2-3 days before it works properly again?
Do you ever use viagra in between?

I just find that if i use it for example Friday and Saturday, that i get benefits on Friday right up until about Monday, sometimes Tuesday. I don’t use anything in between although i have ordered some levitra to experiment with.

I just found that using it a 2-3 days and then a few days off works best. If i take it for (i’d estimate) 6-7 days straight, i’d become almost automatically immune to it and literally not have any benefits until i go off and then re-cycle.

Saturday - Cialis 20mg
Sunday - Nothing
Monday - Cialis 5mg
Tuseday - Levitra 20mg
Wednesday - Cialis 5mg
Thursday - Cialis 5mg
Friday - Viagra 100mg

The higher dose of cialis, viagra and levitra work better if the tablet is split and taken half an hour to an hour apart.
I also cycle zinc, bcomplex, vit c and vit d which helps with libido … takes from zero to around 20-30% of pre fin libido.
I have been doing this for about 6 months and am having sex 7-10 times a week with my gf.

That’s pretty awesome.

Obviously that cycle works well for you; have you tried a week without as a test?

How does that leave your erections?

And could you explain the difference you find in the effectiveness of each pill individually?

I should add to this thread.

Apparently some studies have suggested that use of cialis etc can actually aid a nautral recovery of erectile performance over time. Who knows how well that pertains to us guys, though.

Without the pills its hit and miss. I only go without during her period so we dont do it that much, but if we do its hit and miss.
I should add for that i have not suffered any shrinkage and so on.

It leaves my erections, always able to have sex, sometimes rock hard sometimes 90% hard.

Cialis high dose is slow to act usaully have to take about 2 hours before sex gives me a good erection for about 2 days. Sides : Sometimes muscle pain usaully weak, maybe on average every second time i take this
Cialis 5mg i take in the morning and it usaully takes a bit longer to kick in, but erections are good for about a day. Sides : None
Levitra gives me rock hard bonners everytime, as i said i split the dose take the first half about 2 hours before sex and the second about an hour. Sides : None
Viagra : Sometimes rock hard sometimes 90%, same dosing rules as levitra. Viagra is a funny one sometimes lots of sides sometimes none, sometimes i cant ejaculate sometimes i can. Sides : Headache, fatigue, muscle pain …

I do get a morning erection doing this along with nocturnals. I try to give myself on self induced erection a day to go with my erection for sex, my nocturnals and my morning so i have fresh blood going to the penis on a semi regular basis.

Generally i tolerate theses meds really well and have had no major sides.

Sorry to highjack the thread.

Nah guys this is awesome information.

Really appreciate it. I may be about to get into a relationship soon, and it will be my first relationship since this fin bs, so im kind of a bit scared that i wont be able to perform after repeatedly using PDE-5 inhibitors, as some ppl have reported building a tolerance on here. I’ve had about 5 one night stands and been able to perform on either cialis or viagra, but these have all been at least a month apart. So regular sex has me scared.

So Mens Rea you take a whole 20mg cialis friday, and another 20mg sat night thats what you are saying yeh?

Tim i remember reading a post many months ago from you where you list this regime, and it was the first thing i had read that gave me some hope that i might be able to lead some kind of almost normal sex life.
Its great to hear that this is still working for you after all this time, and side effects are minimal. Im guessing its quite expensive popping all these pills, or do u take generics?