If you are on TRT and still your Vitamin D is low then please update the thread. Why our vitamin D is low, calcium is high , magnesium is high? This is a million dollar question. If it is not parathyroid then what?
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According to the Norman Parathyroid Center, it’s certain that you have a parathyroid tumor if your calcium is high, and your vitamin D is low.
The clue to the fact that we might be getting vitamin D wrong is when we see deeply tanned Australian surfers, who spend all day in the sun…with low vitamin D levels. Here are my concerns about measuring one chemical at one nano second in time that controls a million year old complex web of interactions and basing recommendations on that.
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Vitamin D is a critical hormone for health that works by binding to vitamin D receptors and altering gene activity. What we are measuring in the blood is 250H vitamin D. This is not the active vitamin D (it has to be activated in the liver and kidneys), there are also enzymes and minerals involved in its action on receptors.
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If our free calcium gets too high (not measured in lab tests) then the body will reduce vitamin D levels to prevent damage from the calcium. That’s the same calcium that gets deposited in our arteries and detected on a CT scan. Adding in large doses of vitamin D in response to a “low” vitamin D level would not be good. We saw the same thing happen when we decided it would be a good idea to lower the blood pressure in people with acute strokes. We scratched our heads and wondered why they did badly until we realised that the body put up the blood pressure to ensure continued blood flow to the brain. Lowering the blood pressure acutely just made the area of brain not getting its blood flow bigger.
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The body has a negative feedback loop with vitamin D from the sun…get too much sun and it stops making vitamin D in the skin. No feedback loop with large doses of synthetic vitamin D.
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Research has shown that low magnesium levels result in low vitamin D levels. If we are low in magnesium…we might not make any even if we get lots of sun. That might might explain why supplementing with vitamin D has not been as therapeutically effective as we expected (see attachment).
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Low vitamin D may be a response to inflammation and not a cause of it. We don’t measure the activated vitamin D because levels are too small to measure. Also vitamin D has its action in cells and tissues, not in the blood. Levels cannot be measured here. It may be that the inactive form of vitamin D we measure is low because more has been converted to the active form in tissues in response to the inflammation. So the deeply tanned surfer with low vitamin D levels doesn’t need vitamin D…he/she needs magnesium and the source of their inflammation/infection determined i.e the low vitamin D is a result of the inflammatory condition, not the cause.
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