Anti-androgens in HPTA restoration

General Discussion
#1

anabolicminds.com/forum/male-ant … -anti.html

Theoretically speaking, and anti-androgen side effects notwithstanding, I think this seems to make sense…

Finasteride would obviously not be appropriate for such a purpose because it does not block 5AR type I (in the brain, and hence hypothalamus).

Avodart (dutasteride) however, does seem to have potential (for those who don’t react strongly to it). I imagine perhaps taking combo Avodart/SERM. This would effectively shut down all androgen/estrogen negative feedback produced in the hypothalamus, which is, as I understand it, the therapeutic mechanism at work when “jumpstarting.” The crucial difference being that while the typical jumpstart involves blocking only estrogen (taxoxifen, clomid), this would also block the other major source of negative feedback, DHT. Also, concurrent use of tamoxifen/clomid would counter any possible harmful estragonic effects of 5AR inhibition throughout the body.

Also, Mew, I remember reading on this site about a guy who claimed to have recovered using Avodart. Do you remember anything about that?

#2

That sounds nuts man!

Type 1 DHT has even more of a role in converting progesterone to allopregnenolone, so you could even have more GABA related negative effects on yourself.

Also Dutasteride has a much, much longer half-life than finasteride, and I have actually read of doctors acknowledging the fact that dutasteride problems can take much longer, like years, to fix themselves.

#3

I agree, it is probably nuts. Especially considering the fact that SERMS only block estrogen in certain parts of the body (e.g. breast tissue, hypothalamus). Adding avodart into the equation would cause a significant increase in estrogen.

The ideal solution, of course, would be a SARM capable of blocking hypothalamus androgen receptors while acting as an agonist at all other locations in the body (except perhaps the prostate, I suppose). This way you’d block negative feedback more completely.