I had a ct scan of my abdominal area from a gi doc and the only thing they found was alot of reason to recommend Miralax.
Id also keep this test in mind, ive tested positive for this antibody.
acetylcholine ganglionic neuronal antibody
Autoimmune GI dysmotility: A new direction
“if the immune system can cause inflammation of the optic nerve, spinal cord or cerebral cortex, then why can’t it cause a problem with the gut? After all, the gut contains 100 million neurons — more than the spinal cord or the peripheral nervous system.”
Immunotherapy trial as diagnostic test in evaluating patients with presumed autoimmune gastrointestinal dysmotility
Ganglionic AChR antibodies are proven to cause AGID in active and passive immunization animal models
Autoimmune Dysautonomia Evaluation, Serum
https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/92121
The most commonly encountered autoantibody marker of autoimmune dysautonomia is the neuronal ganglionic alpha-3-acetylcholine receptor (AChR) autoantibody. This autoantibody to date is the only proven effector of autoimmune dysautonomia
Regarding 6475, it activates h1 and h2 receptors, but supposedly blocks inflammatory h1 effects by a metabolite the bacteria produces.
HISTAMINE PRODUCTION
BioGaia’s L. reuteri strains have anti-inflammatory effects
Production of histamine is the prerequisite for one mode of action
L. reuteri ATCC PTA 6475, 5289 and 4659 can produce histamine
L. reuteri DSM 17938 can’t produce histamine
Histamine production and anti-inflammatory effects
L. reuteri ATCC PTA 6475 (6475) can produce histamine in the intestine
In the cell membrane of epithelial cells you find 4 different histamine receptors,
of which the first two are key receptors in inflammation
When histamine binds to H1R, inflammation is induced
When histamine binds to H2R, inflammation is reduced
6475 can also produce the enzyme diacyl-glycerol kinase, DagK
DagK degrades diacyl-glycerol in the cell wall of the epithelial cells and thereby blocks the pro-inflammatory pathway connected to the H1R
The histamine that binds to H2R, results in a reduced inflammation
^This is immunosuppression. I have thought more of this being a bad thing in our case initially though, so im still careful about this.