Androsterone in men

General Discussion
#1

Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men.

Conclusion: These data suggest that the neurosteroid androsterone contributes to the regulation of sexual function in men.

archpsyc.jamanetwork.com/article … eid=209516

Androsterone is the active main ingredient in androhard and alphahard which was a part of cdnut’s protocol. I thought this article was especially interesting since it talks about inducing hypogonadism in men, which is whats happened to us.

“The symptom of decreased sexual interest did not correlate with CSF measures of testosterone, dihydrotestosterone, or DHEA, all of which are reported to increase sexual interest when administered to hypogonadal men.10,11,47 However, we observed that decreased sexual interest significantly correlated with CSF measures of androsterone. The correlations with CSF androsterone were observed during both the hypogonadal and testosterone-replaced conditions; in addition, the magnitude of the decrease in sexual interest correlated with the magnitude of the decrease in CSF androsterone levels across conditions. Thus, regardless of the hormonal state, the association between decreased sexual interest and CSF androsterone levels (but not other androgens measured) remained significant. Our findings, then, suggest that CSF androsterone contributes to the regulation of sexual interest in men.”

I suggest you all read this article, its very interesting and I think may shed some light into our condition.

1 Like
#2

ELI5 anyone?

#3

CSF = Cerebral Spinal Fluid. Androsterone and Epiandrosterone are 5-alpha-reductase metabolites of DHEA. The main ingredient in Androhard was (I believe, Epiandrosterone). But the interesting thing about this is that many men here have tested 3-alpha-diol-G levels (which is related to this stuff), and it was out of range for many of them.

I am of the STRONG opinion that checking the entire 5-alpha-reduced family of steroids in the CSF will show an OBVIOUS problem in men the PFS vs men without.

If I had any god damn money I would pay you all for samples of your CSF to get tested, and we would have the answer in a month.

#4

So does any of this point to a cure?

#5

I do believe the Italians are further looking into this steroid pathway and will be measuring all these hormones in the upcoming study. I think its interesting that supplementing androsterone/epiandrosterone may have contributed to cdnut’s recovery. It may be that when you increase androsterone in PFS you may help balance out some hormones which can then let the body correct itself. Again, this is speculation, but I do remember CDnuts posting before he fully recovered that when he took androhard he felt almost 100% normal. His body may have needed time with androsterone to equilibrate. I’m sure Dr. Bhasin who’s leading the BWH study has insight into this.

Here’s another interesting study.

Plasma androsterone/epiandrosterone sulfates as markers of 5 alpha-reductase activity: effect of finasteride in normal men.
Lewis JG1, George PM, Elder PA.

Abstract
Plasma androsterone/epiandrosterone sulfates, dehydroepiandrosterone sulfate, dihydrotestosterone, testosterone, androstenedione, and cortisol were measured in three normal adult men before and following finasteride administration (5 mg/day). Plasma androsterone/epiandrosterone sulfates and dihydrotestosterone declined in parallel to 50% of basal levels with little change in either dehydroepiandrosterone sulfate, cortisol, or androstenedione. The results suggest that the direct measurement of plasma androsterone/epiandrosterone sulfates by enzyme-linked immunosorbent assay provide similar information to plasma dihydrotestosterone and therefore provide a simple alternative for the assessment of 5 alpha-reductase activity.