It’s no wonder we get hit with mental symptoms we have 3 categories of AR receptors in the brain. This is troubling. Dht in the brain acts on the central nervous system. So after reading this I assume we don’t have brain damage yet but rather AR receptors not functioning properly. What the long term consequences of this I don’t know.
It is proposed that there are three categories of receptors for androgen in the brain. One receptor preferentially binds testosterone and a second one preferentially binds DHT. Both of these receptors are in equilibrium between nucleus and cytoplasm according to the free water content of the compartments. Both of these receptors can be activated and transformed by steroid and thus concentrate in the nucleus. It is proposed that a third receptor binds both steroids with the same relative affinity. However, this third receptor can only be activated but not transformed (i.e. it does not concentrate in the nucleus). The proposed system implies that testosterone acts on a few discrete populations of neurons in the brain while DHT has a very diffuse action on the central nervous system.