androgen receptor blockage by a 5ar inhibitor

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#1

This is a study on Saw Palmetto, which is also a 5ar inhibitor and also can lead to PFS. If SP can actively block the receptor, then why would we assume that Finasteride cant?? The only question is why it would continue to be blocked after all these years…

Other studies have shown that Serenoa extract inhibits androgenic activity by competing with DHT for the androgen receptor, thereby affecting testosterone metabolism.13 The binding of two synthetic androgens, mibolerone and methyltrienolone, that are specific for androgen receptors at low concentrations (5nM), were inhibited by Serenoa extract (Permixon) in a competitive manner. Various plant steroids were tested for competitive binding to androgen receptors and found to be inactive.13,14 The inhibitory effect of Serenoa extract on DHT and testosterone binding was tested in tissue from 11 BPH patients. An average of 40%-42% reduction in receptor binding was observed for both hormones.15

legacy.uspharmacist.com/oldforma … icle_id=87

[i][b]The bioactive substances in saw palmetto may actually interfere with the function of testosterone by blocking the androgenic and anabolic receptor sites of cells that testosterone needs to bind with to turn on cellular protein synthesis.

Saw Palmetto may actually interfere
with the function of testosterone.

Tests using tissue samples revealed that substances in saw palmetto actually reduced the tissue uptake of testosterone and dihydrotestosterone, which means saw palmetto bioactives blocked these anabolic hormones from entering cells, which is very anti-anabolic. [/b][/i]

bodybuilding.com/fun/gastelu21.htm

#2

A recent realization of mine is there seems to be a default assumption even among medical people that the endocrine system has a elasticity, like many other body systems/processes. It simply may be wholly untrue that after one alters the delicate balance there is any mechanism that aims to return it to the original state.

#3

There are people who have recovered months/years later naturally, so there must be. Take this guy for example: viewtopic.php?f=3&t=695

But in the end, like most things concerning this condition, I think it really just depends on the person.

#4

Check out these 2 studies from June 2013. This is proof that Finasteride (just like Saw Palmetto) is not only a 5ar inhibitor, but it also acts directly on the Androgen Receptor!

[Size=4]The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific[/size]

onlinelibrary.wiley.com/doi/10.1 … 6/abstract

CONCLUSIONS

The direct inhibitory effect of dutasteride or finasteride on AR signaling is cell line specific. Mutations in the ligand binding domain of AR do not appear to play a significant role in influencing the AR antagonistic effect of these drugs. Subcellular constituent is an important factor in determining the drug effect on AR function

[Size=4]Prostate cancer cells differ in testosterone accumulation, dihydrotestosterone conversion, and androgen receptor signaling response to steroid 5α-reductase inhibitors[/size]

onlinelibrary.wiley.com/doi/10.1 … 4/abstract

CONCLUSIONS

The biological effect of finasteride or dutasteride appears to be complex and may depend on the interplay of several factors, which include testosterone turnover, enzymology of DHT production, ability to use testosterone and DHT interchangeably, and propensity of cells for off-target AR inhibitory effect.

#5

Good find moonman, these last 2 studies are certainly thought provoking.

#6

if you do an google scholar search on finasteride, in 2013 there are tons of new studies. A very good thing for all of us.