Complete androgen insensitivity syndrome is treated with estrogen replacement therapy after puberty. Undescended testicles will be surgically removed because of the risk that they will become cancerous. Treatment for partial androgen insensitivity syndrome may include corrective surgery to match gender identity.
Mild androgen insensitivity syndrome is a condition that results in a mild impairment of the cells ability to respond to ANDROGENS.
Also from later in the article:
Due to its mild presentation, MAIS often goes unnoticed and untreated.[15] Management of MAIS is currently limited to symptomatic management; methods to correct a malfunctioning androgen receptor protein that result from an AR gene mutation are not currently available. Treatment includes surgical correction of mild gynecomastia, minor hypospadias repair, and testosterone supplementation.[1][15][54] Supraphysiological doses of testosterone have been shown to correct diminished secondary sexual characteristics in men with MAIS,[15] as well as to reverse infertility due to low sperm count.[54][55] As is the case with PAIS, men with MAIS will experience side effects from androgen therapy (such as the suppression of the hypothalamic-pituitary-gonadal axis) at a higher dosage than unaffected men. Careful monitoring is required to ensure the safety and efficacy of treatment.[15][56][57] Regular breast [56] and prostate [58] examinations may be necessary due to comorbid association with breast and prostate cancers.
just pointing this out in case people think estrogen is the only solution for these patients.
This isn’t Androgen insensitivity syndrome as other members have had AR ligand binding determined. It is normal. And CAG repeats is normal.
Yeah I think this is completely different from PFS. Dont anyone dare try to inject estrogen lol.
How you get AIS is not the topic for discussion. The symptoms, treatment and medical research for the condition is more important.
Certain symptoms of AIS can be found in PFS and are the same. Please do your own reading on this.
Treatment can go from taking high amounts of T to more extreme cases using physical castration and estrogen TRT. Basically they are saying that a person needs T or E to function normally. In PFS would castration and estrogen TRT give someone a normal life again? I don’t know the answer as E is normally given at puberty which we have already been through with male hormones. Would the worst cases with PFS be better off on estrogen TRT and effectively becoming a women?
AIS appears to be a genetic condition that could potentially be reversed by Crispr in the future. However science doesn’t seem too concerned about curing AIS which has similar symptoms to PFS. The current treatments for AIS have not really advanced and this is a recognised condition.
Agreed, just the known molecular mechanisms to cause AIS are not the same as PFS based off what we know