An input for those looking into the inflammation problem

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Many here have problems with inflammation and the first thing it comes to mind (and honestly this is the only theory I have read in PH) is leaky gut or similar pathologies due to imbalanced gut bacteria flora or similar. I am not studying PFS in depth anymore and I never studied the inflammation problem: I have decided for myself that the best approach is healthy living(toghether with many practices) so I just leave you with this short infos you might want to investigate deeper. Inflammation problems might have a neurological origin, or at least a neurological cofactor. This web article poses to us the question if we have looked in the right place. Leaky gut might not be the cause of inflammation, but an overreactive local immune system might be, when activated improperly by local nerve cells. Othe studies should be searchead at least to avoid being mislead by the leaky gut theory which might not be our case. Also If I were you, I’d look into articles correlating neurosteroids, pelvic/cavernous/pudendal/dorsal nerves with local inflammation.

medicalxpress.com/news/2016-01-n … ation.html

In other experiments, the scientists found that muscularis macrophages carry receptors on their surface that allow them to respond to norepinephrine, a signaling substance produced by neurons. The presence of the receptor might indicate a mechanism by which neurons signal to the immune cells to put a stop to inflammation.
The researchers also observed that the muscularis macrophages are activated within one to two hours following an infection—significantly faster than a response would take if it were completely immunological, not mediated by neurons. They believe that was because these deeply embedded macrophages receive signals from neurons, they are able to respond rapidly to an infection, even though they are not in direct contact with the pathogen.
“We now have a much better picture of how the communication between neurons and macrophages in the intestine helps to prevent potential damage from inflammation,” says Mucida. "It’s plausible that a severe infection could disrupt this pathway, leading to the tissue damage and permanent gastrointestinal changes that are seen in diseases like irritable bowel syndrome.