May prevent bone loss.
An Exopolysaccharide Produced by Bifidobacterium longum 35624® Inhibits Osteoclast Formation via a TLR2-Dependent Mechanism
Going to link a few things here,
Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics
https://academic.oup.com/femspd/article/63/1/129/549169
Severe acne treated with Isotretinoin is associated with dysbiosis and its consequences
Isotretinoin is known to impair stem cells renewal and TLR2 expression in the mucosa of the
small gut
Conclusion: Isotretinoin is associated with dysbiosis and signs of dysimmunity. A facilitating role of Propionibacterium cannot be excluded.