To be honest guys, i cant get why we dont just collect some money, and get someone of the most affected by PFS among us, try it.
I really have high hopes of SAGE 217, becuz i truly believe, that PFS is some sort of neurological problem.
I dont want to start suggesting theories, that i cant even prove, but the fact, that PSSD and PFS share a lot in common, and lead to the same symptoms, tells me, that it is some sort of Brain-issues. On the other hand i truly doubt that the Andorgen receptor is not working. Androgen receptor is very well studied, and it would have been easy to decipher our issues, if it was the problem.
I think, that the 5-alpha reductase in our brain have been compromised, and im not speaking of total DHT in our blood, that can come from different sources (Same as you can have 0 DHT and still lose hair, bcuz its the local production in the hair follicle that counts).
Its the local production of reduced Steroids, what makes us sick. When we are deprived from our neurosteroids, we end up in a devil cycle of compromised 5a-reductase (Which btw the rate limiting enzyme for Allo and co. production, and that makes me think, that it is far less synthesized in depressed patients), compromised Neurogenesis in the Hippocampus (And just for fun in the olfactory bulb, as i have lost my sense of smell completely for nearly 1,5) due to basically no more available Neurosteroids (Allo controls the neurogenesis in those areas, and without it, we get memory loss, depression, brain fog, you name it), and our body cant come out of it, becuz depression leads to reduced Neurosteroid production, and reduced neurosteroid leads to depression.
I know, some of you will bash me, becuz lots are suffering from physical changes, but again, normally depressed people have those changes too, let alone We, who are no only normally depressed, but really F* up, anxious, majorly depressed, cant sleep and so on.
If the changes in 5a-reductase is epigenetic, which i think, it is. (The expression of those enzymes are likely to be controlled through DNA mythelation), then we are truly F*, not becuz its not reversible, Epigenetic changes can be reversed, but only slowly. We are f* up, becuz noone will ever be able to study PFS in the next 60 years until enough of us have died, and our brains got examined. (Most of pfs sufferers are young, and this s* wont kill any sooner.
Its just my theory, and ofc i cant prove any of it, but to be honest, if there is little hope for us, it would be SAGE 217 in my opinion.