I thought this study was interesting. If we find less than definitive answers down the line, this might be an example of why you start to look at everything. Meaning a life or health issue triggered by but not restricted to the drug itself.
Age and Obesity Promote Methylation and Suppression of 5-Alpha Reductase 2–Implications for Personalized Therapy in Benign Prostatic Hyperplasia
We found that both BMI and age independently predict increased 5AR2 gene methylation as well as decreased 5AR2 protein expression in BPH specimens of symptomatic men. While 5AR2 has been previously thought to be ubiquitously expressed in order to drive prostatic growth similar to its function in embryologic development,18, 19 our work suggests that 5AR2 protein expression in the adult prostate is variable and may be intimately connected to widespread epigenetic changes that occur with obesity and aging.