Where are you from (country)?
How did you find this forum (Google search – if so, what search terms? Via link from a forum or website – if so, what page? Other?)
What is your current age, height, weight?
Age 32, 3’2", 119 pounds
What specific drug did you use (finasteride, dutasteride, saw palmetto, isotretinoin/Accutane, fluoxetine, sertraline, citalopram, leuprorelin, etc…)?
Adapalene (C28H28O3) a topical retinoid. I used an SSRI as a child.
What dose did you take (eg. 1 mg/day, 1 mg every other day etc.)?
Enough to cover my face day and night.
What condition was being treated with the drug?
For how long did you take the drug (weeks/months/years)?
About a week, then again for a couple weeks w/ oil to attempt to withstand dryness.
How old were you, and WHEN (date) did you start the drug?
How old were you when you quit, and WHEN (date) did you quit?
How did you quit (cold turkey or taper off)?
How long into your usage did you notice the onset of side effects?
Immediately, probably day one and then an increase in symptoms immediately every time I put it on.
What side effects did you experience that have yet to resolve since discontinuation?
All of them aside from eczema on my face.
Dryness, internal dryness, digestive issues, rapid heartbeat, fatigue, headaches, muscle aches, sexual issues, mental focus, eye issues, sleep troubles, loss of vivid dreams.
Check the boxes that apply. You can save your post first, then interactively check/uncheck the boxes by clicking on them. If your symptoms change, please update your list.
Loss of Libido / Sex Drive
Loss of Morning Erections
Loss of Spontaneous Erections
Loss of Nocturnal Erections
Inability or Difficulty to Ejaculate / Orgasm
Reduced Sperm Count / Motility
Emotional Blunting / Emotionally Flat
Difficulty Focusing / Concentrating
Memory Loss / Forgetfulness
Stumbling over Words / Losing Train of Thought
Slurring of Speech
Lack of Motivation / Feeling Passive / Complacency
Extreme Anxiety / Panic Attacks
Severe Depression / Melancholy
Penile Tissue Changes (narrowing, shrinkage, wrinkled)
Penis curvature / rotation on axis
Testicular Shrinkage / Loss of Fullness
Genital numbness / sensitivity decrease
Gynecomastia (male breasts)
Dry / Dark Circles under eyes
Persistent Fatigue / Exhaustion
Stomach Pains / Digestion Problems
Constipation / “Poo Pellets”
Vision - Acuity Decrease / Blurriness
Tinnitus (ringing or high pitched sound in ears)
Increased hair loss
Lowered body temperature
Other (please explain)
Chronic infections, yeast, trouble keeping eye focused, twitching, crawling sensations on skin, food intolerances, yellowing of skin, weight loss, nausea, pain in gut, extreme fatigue and weakness when lifting arms, nerve-like pains, slowness, hypothyroidism, pain during orgasm, tightening of body.
What (if any) treatments have you undertaken to recover from your side effects since discontinuation of the drug?
Antibiotics, antifungals, 5HTP, vitamins and minerals, diet adjustments, brief chelation, antihistamines, thyroid medication, DHEA, and others…
If you have pre or post-drug blood tests, what hormonal changes have you encountered since discontinuing the drug (please post your test results in the “Blood Tests” section and link to them in your post)?
No pre-drug test results as I never needed any.
Post drug, I had:
High TSH, low T3 and T4 hormones. Low free T and E, on occasions.
Low B6, low B2, low alkaline phosphatase.
Organic Acids: High Arabinose (yeast) Over twice upper limit of normal.; High Hippuric (bacteria) Over twice upper limit of normal; Low Glycolic; High Lactic; High Fumaric, Malic, 2-Oxoglutaric, Aconitic, and Citric.
Mitochondrial marker 3-Hydroxyglutaric was High.
Dopamine marker HVA was normal with VMA epinephrine marker slightly higher but normal.
5HIAA serotonin marker low, almost nothing, but no low normal value is listed.
Quinolinic normal but ratio to 5HIAA was VERY high.
Ketone and Fatty Acid Oxidation markers Methylsuccinic, Adipic, Suberic all high.
Salicylate marker was normal.
Glutathione markers were normal.
Positive for some (semi specific) bacteria.
Inflammatory marker Calprotectin normal.
Anti-gliadin IgA was High.
Sjorgren antibodies 0.
High Intolerances to many foods and yeast.
All other standard tests so far normal, including B12 and D2. Autoimmune markers normal.
Anything not listed in the above questions you’d like to share about your experience?
Tell us your story, in your own words, about your usage and side effects experienced while on/off the drug.
On: Sandpaper eyelids, eczema on my face and worsening of cystic acne. Bizarre insomnia and energy. 8X daily BMs. Headaches. Rapid weight loss.
The day I stopped: Slowing of BMs, extreme faitgue, aches, skin begins to yellow, metal focus deteriorates, weird nightly depression grows into chronic fatigue, bloating, weight gain and then weight loss again, and more and more for the past 6 years.
I’m including all this here in the hope that someone reads it and an answer-light switches on.
Edited to add:
FSH was normal a couple years ago.
Recent Estradiol on day 2 was normal (low end, but hard to say if that mean anything on day 2)
Testosterone normal, middle range…