Action of Human Growth Hormone (hGH) on Extrathyroidal Conversion of Thyroxine (T4) to Triiodothyronine (T3) in Children with Hypopituitarism

Science Other Studies
#1

LINK: journals.lww.com/pedresearch/Abs … _on.2.aspx

INTERESTING, COULD THIS BE WHY PEOPLE WHO GO ON HGH FEEL BETTER SEXUALLY? Is it because HGH lowers Reverse T3 levels and increase T3 levels? INTERESTING READ!

Abstract

Summary: To study the action of human growth hormone (hGH) on peripheral metabolism of serum thyroxine (T4), an oral loading dose of levothyroxine (1.2 mg/m2) was administered to seven children with hypopituitarism before initiation of hGH therapy. Serum concentrations of triiodothyronine (T3), T4, reverse triiodothyronine (rT3), and thyroxine-binding globulin (TBG) capacity were measured sequentially for 6 days. The study was repeated after 4 wk of treatment with hGH. Serum concentrations of T4 were not affected by hGH therapy. In contrast, mean basal serum concentration of T3 increased significantly after treatment with hGH. Also, changes in serum concentrations of T, and in the ratio of T3/T4 after an oral dose of levothyroxine were significantly augmented during hGH therapy. Serum concentrations of rT3 changed in the opposite direction of T3 during therapy. After treatment with hGH, the mean basal level of serum rT3, decreased, and increases in serum concentrations of rT3, after oral levothyroxine were significantly attenuated. No changes in mean serum concentrations of thyroid stimulating hormone (TSH) and TBG capacity were observed.

© International Pediatrics Research Foundation, Inc. 1981. All Rights Reserved.

#2

anonnne1,

I posted a link a while back regarding IGF-1 levels and low functioning thyroid. I don’t believe treatment with HGH is not the answer though, as the low IGF-1 (HGH) levels are a result of thyroid problems rather than the other way around. It is also a rather controversial drug that has risks associated to it as well. JN, used that for a while and his skull got larger in a disproportionate way. Have you ever seen Roger Clemens before and after HGH?

It is also incredibly expensive. If you want insurance to cover it, you need to be diagnosed as HGH deficient. They have to run a specialized test that verifies your Pituitary gland can no longer produce sufficient levels of growth hormone.

The correlation between thyroid problems and low IGF-1 or HGH is there and it’s a good reason why many need to include these hormones when having a blood test done.

#3

I agree Boston…Just doing a lot of research as usual…Trying to find the solution, so we can move on, heal, get healthy, and then move on to our next agenda…

$$$