About to start Daily Tadalafil (Cialis). Really Nervous! Any long term success?

Ive been taking 5mg every other day. It really helps out but Pre-mature ejaculation is still present

Been on a couple of months of 5mg ED. 25mgs MWF. Don’t have an issue performing. Sensitivity does not seem to have improved much. Getting more frequent nocturnals.

I just came across this (i can’t see the full article):

My urologist suggested taking it daily(except for the day with any sexual activity, in that case I should use sildenafil). I’ve been following this scheme for several months.
I observed solid improvement in erection quality(the shaft finally returned to the normal condition, the tip has partially improved) and regular nocturnals/morning wood. Also there was some minor improvement in senistivity too. But no improvement in libido/sexual sensations/orgasm.

I have developed quite annoying tinnitus and weird feeling of tension inside my head(but absolutely no headaches or dizziness). These are likely to be the tadalafil side effects.

I tried to stop taking it for a few days to see if the tinnitus would go away and all the good effects would stay. Nope. The tinnitus never faded and I experienced even bigger decrease in libido and some ED.
I assume it could be a coincidence(I had some bad sleep those days).

This is exactly my experience as well.

I can almost say that with Cialis I feel 90-95% recovered however i do not want to rely on this drug. Numbness is still an ESPECIALLY annoying issue off the drug

If Cialis makes this huge of a difference for us… there MUST BE a path to FULL recovery.

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Also now experiencing constant tinnitus, I think as a result of the cialis. Not sure though. Seems like a very rare side effect — and it came on after months of taking cialis daily. Off it for a week and no change to the T.

Since it’s not really improving libido I’m afraid it’s merely a treatment of symptoms.

I think we have sustained some sort of brain dysregulation or damage. To me that seems the core problem of PFS. Imagine still having the raging libido and excitement about life in general, with just the erection problems. I would sign for it right away… The psychological symptoms like non-existent libido, flat emotions and loss of excitement are the worst to me.

I have just started using 2.5mg of tadalafil once a day again. I’m considering using 2.5mg eod because of it’s long half life.

I’d be careful with cialis tbh. It really fucked me up, gave me a myriad of muscle and skin issues I didn’t have before.

It’s shown to upregulate AR in muscle cells, so it makes sense that if we already have to much AR it’s not very good for us.

Would you mind clarifying what the muscle/skin issues were that you experienced as a result of cialis?

Sure. I’ve been planning to add it to my story with the report form but haven’t had the energy to yet.

Muscle - loss of muscle tone, loss of “feeling” when contracting the muscle, in rest the muscles are super soft, not able to get a pump (or at least feel it), loss of vascularity. Also pain in lower back and knees due to the loss of muscle tone (no stability).

Skin - loss of elasticity, when pinching the skin it would take 4-5 seconds for it to go back to normal. Loss of sebum / fluid all over face and penis.

My penis was so dry I could not pull back the foreskin before I quit the cialis. Also penis pain that I didn’t have before, further loss of sensitivity (it’s 100% numb now).

I guess that’s core of it. Some things improved after I quit, the skin feels more pliable but most thing didn’t change sadly.

I’m 100% sure it was due to daily cialis (5mg). Took just over a month to start noticing the bad effects.

Edit: Also forgot to add that I got really severe pain in my fingers, it was so bad I couldn’t hold my phone. Thank god this went away quickly as I stopped.

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“The in vitro increased myogenin and androgen receptor protein expression in skeletal muscle cells suggests a translational action of phosphodiesterase type-5 on this receptor.”

This part does indeed scare me. If (part of) our symptoms are because of hypothetical induced apoptosis after over activity of androgen receptors, tadalafil might indeed worsen our symptoms.

On the other hand N=1 and your experience might have so many other causes which are hard to identify. There are numerous people on the forum with good experiences on tadalafil.

I’ve been on daily tadalafil 5mg for 2 years almost (with a half a year break in between somewhere) and haven’t experienced any worsening or negative effects (apart from normal sides such nasal congestion and some flushing when I have just taken it).

Yeah that’s true. People react to everything a lot differently after all. But in my case I’m sure it was the cialis due to the time line, especially how it all quieted down shortly after I quit. I had been stable for almost 2 years before my trial.

I did get a few pms from people who experienced similar issues though after I posted my story here before.

I’d say most have neutral experience, it helps them get an erection while using but it actually “repairing” something I haven’t seen much of.

In my opinion I’d rather use daily viagra, as it seem to have no interaction with androgen receptors and it works the same for the penis (although shorter half life).

I tried 50mg before bed for over a month and I woke up with erections every day, with no ill effects, but sadly didn’t help my sensitivity either.

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Sildenafil has a similar mechanism of action to tadalafil but with a shorter half life. Do you have any ideas about why sildenafil does not cause any of the side effects you experienced?

I’m taking the tadalafil for preservation and support of the vasculature. Not to perform better, unfortunately, since I never “perform” any more.

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Not really, but I think it might be due to greater potency of inhibiting PDE11.

Cialis Back Pain May Be Due To Greater PDE11 Affinity Than Viagra, Levitra

Tadalafil is extremely selective for PDE5, but also potently inhibits PDE11, an enzyme with unknown physiological function.