Guys, I’m aware that some people have more extensive damage than others. I’m posting here what I believe are some elements that can be used by some to try and get better.
I’m also aware that it’s not a complete protocol (if ever there is one). I’m just discussing the difference between ketosis and fat adaptation, the benefits of eliminating carbs and allergens, at least in the early stages of the disease, and the benefits of fasting, which is good whether or not someone is fat adapted; fat adaptation making it easier.
According to my researches on epigenetics, it appears that aging is in great part due to epigenetic damage. I have an old friend whose skin is falling apart. He’s got small wounds spontaneously appearing all over his body, out of nowhere. Epigenetically, this can be explained by the skin cells having forgotten their role as skin cells and producing a different set of protein than they are supposed to (aka: reading genes inappropriate to their cell type). Those wounds are skin cells acting as flesh cells or something else. This looks a lot like the skin problem of some pfs sufferers and it’s just one example.
I’m still looking at Harvard’s researcher Dr. David Sinclair who has found, among other things, how to remove methyl groups on specific DNA sequences, or use designer viruses to alter some DNA sequences, loosen the histones to get a better gene reading aka protein production, and many more: increased growth hormones, production of stem cells, production of new neurons, more mitochondria and some other stuff I can’t understand yet.
I believe something of a remedy is coming, but it won’t be for our specific condition but rather to the larger group of general epigenetic damage.
Meanwhile, here are Dr. Sinclair’s easy and safe tricks to reverse epigenetic damage caused by aging:
- Do some water fasts or be hungry often.
- Take cold showers or hot saunas (or both)
- Do some exercise and get out of breath. Running seems to be a good choice.
- Doing weight lifting was suggested to me by my endocrinologist as a way to raise testosterone and create extra androgen receptors.
(you will find many of those elements in the Success Stories)
Dr. Sinclair also has drugs he’s using, but do your research and be extra careful. I never advise people to take drugs as I’m not a specialist and I know it can have very adverse effects. Nonetheless, here are the drugs he’s using himself:
- Metformin 500 mg on resting days, not on exercise days
- Resveratrol, he uses 1 or 2 gr a day, taken with yogurt, but it’s been pointed out on this forum that it’s 5-ari and can be dangerous to us. I don’t advise trying it. Taking fresh, unheated extra-virgin olive oil can have a similar effect and be less dangerous. If the oil smells rancid, it’s toxic and should be discarded.
- Using NAD+ Boosters. I need more info on this one.
A Russian doctor specializing in epigenetic damage suggest eating only meat. Of course, this also produces more TOR enzyme which ages the body, but it’s been my experience that eating only meat and animal fat, especially from ruminants, has eased my symptoms. This is always my go back to solution when I’m feeling bad.
I’m not proclaiming a cure, I’m not even saying I’m cured myself, I’m just suggesting elements that can help some of us. Obviously, the least affected will be the ones easier to improve. And please: don’t take anything as an insult. I’m just trying to help and showing that science is actually moving forward.
By the way, a 3000 year old stoic trick to be impervious to insults is humility. I myself try to stay as humble as I can, with mixed results, but whenever I manage to be humble no insults can trigger emotions in me. I just acknowledge someone has said something, I’m for freedom of speech so that doesn’t bother me, and the reaction I choose to have is all in me and unrelated to outside influence.
I wish the best to you all. I will post again when I have more (especially how to boost those methyl cutting protein we can produce…)