Many of the good people here mention an apparent loss of collagen due to thinning skin, excessive elasticity of skin, and loss of volume in facial structure.
The following study found that male mice with a dysfunctional AR had “visibly” reduced collagen content in skin and that even female mice with dysfunctional AR had “slightly” reduced collagen compared to normal controls:
Collagen, the major macromolecular component of skin, is responsible for maintaining the structural integrity of the tissue as well as for providing important functional characteristics, such as pliability and thickness. We have been studying the structure and regulation of collagen in mouse mutations affecting the skin. In the course of these studies, we found that there are significant differences in collagen content between the skin of wild-type male and female mice, which become evident at puberty. Furthermore, male mice with an X-linked mutation in the androgen receptor gene (formerly called testicular feminization and abbreviated as Ar(Tfm)) showed decreased levels of collagen, indicating that the androgen receptor pathway contributes to the observed differences. These findings demonstrate that there are striking differences in the collagen content of skin between male and female mice, and provide a biochemical explanation for these differences.
Histopathological analysis of skin samples showed that ArTfm/Y males have visibly less collagen than wild-type males (Figure 1b, d). In addition, ArTfm/X females have a slightly decreased amount of collagen compared with wild-type females (Figure 1a, c)