A possible role for retinoid signaling in thermoregulation

General Discussion
#1

The ability to maintain body temperature.
Cold penis, cold skin, hands, face, lack of color or paleness.
One possibility.
I actually maybe had this going on a little bit before Accutane.
I was diagnosed with Raynaud’s (considered to be a vascular disease) pre Accutane

Featured snippet from the web

Retinoic Acid = more than 500 genes.

Brown adipose tissue
Its primary function is thermoregulation . In addition to heat produced by shivering muscle, brown adipose tissue produces heat by non-shivering thermogenesis. … Brown fat also contains more capillaries than white fat . These supply the tissue with oxygen and nutrients and distribute the produced heat throughout the body.

Chronic alcohol consumption decreases brown adipose tissue mass and disrupts thermoregulation: a possible role for altered retinoid signaling

Some would say what would this have to do with Fin or SSRI’s?
Id say there was maybe already an underlying issue to begin with, just waiting to be revealed by a triggering event.

#2

Here’s another one.

Vitamin A Boosts Thermogenesis and Energy Metabolism in Cold Conditions

To produce and maintain body heat, humans and other warm-blooded animals produce heat through energy metabolism in a process known as thermogenesis.

Vitamin A plays an important role in whether adipose tissue is brown, white, or beige, especially in cold temperatures. A recent study demonstrated the role of cold temperatures in mitigating the influence of vitamin A on adipose tissue as a way to regulate cold adaptation, which in part relies on additional brown adipose tissue for increased thermogenesis. Vitamin A aided in the increase of thermogenic gene expression and energy metabolism, stimulated by the cold temperatures as part of adaptation to the environment.