A pharmacogenetic survey of the androgen receptor (in PFS).

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#1

A pharmacogenetic survey of androgen receptor (CAG)n and (GGN)n polymorphisms in patients experiencing long term side effects after finasteride discontinuation. ncbi.nlm.nih.gov/pubmed/24855036

Abstract

Finasteride is a steroid 5-alpha-reductase inhibitor, approved for the treatment of androgenetic alopecia (AGA) and benign prostate hyperplasia. In some patients the treatment is associated with adverse side effects that could become persistent after therapy discontinuation, resulting in the so-called post-finasteride syndrome (PFS).

A pharmacogenetic component in the response to finasteride treatment was previously demonstrated. Two polymorphisms (CAG) rs4045402 and (GGN) rs3138869 in the gene encoding for the androgen receptor (AR) have been hypothesized to play a role in finasteride sensitivity. We aimed to compare the rs4045402 and rs3138869 polymorphisms prevalence in a group of 69 selected subjects (AGA+PFS) that used finasteride to treat alopecia and developed persistent side effects, with that in a group of 91 untreated subjects with AGA (AGA), and a group of 76 untreated subjects without AGA (NO-AGA).

The rs4045402 and rs3138869 polymorphisms extreme-lengths alleles were more frequent among AGA+PFS (odds ratio, 5.88; 95% CI, 1.87-18.52) and AGA subjects (odds ratio, 3.55; 95% CI, 1.13-11.21) than among NO-AGA subjects, probably reflecting the genetic predisposing factors for AGA development. In conclusion, we described a predictive effect of the less common repeats’ length CAG-rs4045402 and GGN-rs3138869 on AGA development. Prospective trials are required to confirm our findings also in other ethnicities, and to highlight possible further pharmacogenetic predictive markers of susceptibility to adverse effects.

#2

this is great, i m pretty sure we will have the cure very soon.

#3

Oscar- what exactly can we derive from this study?

#4

My interpretation is that they established a genetic predisposition for baldness, but not for PFS. Helpful if you’re trying to figure out if you’re going to go bald at some point; not so helpful if you want to find a genetic predisposition for pfs. Hopefully the other studies will find that.

#5

Is it from Italy?

#6

Judging from the names yep!

#7

I think this study recruited in 2011. So a publication in 2014 is a very long wait.

Also, most of the authors of this paper where at a 2011 seminar in Italy about PFS storage2.evectors.com/files/site … nitivo.pdf. This is the same seminar where results from the skin biopsies where shown.

You might also be interested to learn of a new study in Italy that is focusing on the 5a-Reductase enzyme in PFS (Finally!) and not the androgen receptor.

#8
#9

I think this study was huge. I wonder why didnt anyone talk about it. It shows some genetic predispostions for pfs.

#10

if 5ARs are at fault then why not taking DHT can fix the issue?

#11

I have told you my own thoughts on that 100 times spstriken!

This study hasn’t found anything unusual.

In fact there probably isn’t anything unusual about Androgen Receptor DNA in PFS patients - viewtopic.php?f=27&t=2216&p=16463&hilit=repeats#p16463