a direct study connecting fin and Histone deacetylase inhibitors

golf · May 25, 2018, 6:24am

Progesterone treatment has previously been reported to promote the differentiation of glial cells probably through the production of 5alpha-reduced neurosteroids, resulting in the enhancement of serotonin-stimulated brain-derived neurotrophic factor (BDNF) gene expression, which is considered to contribute to the survival, regeneration, and plasticity of neuronal cells in the brain and hence has been suggested to improve mood disorders and other symptoms in depressive patients. Based on these previous observations, the effects on glial cells of histone deacetylase (HDAC) inhibitors, which are known as agents promoting cell differentiation, were examined using rat C6 glioma cells as a model for in vitro studies. Consequently, trichostatin A (TSA), sodium butyrate (NaB), and valproic acid (VPA) stimulated glial fibrillary acidic protein (GFAP) gene expression, and their stimulatory effects on GFAP gene expression were inhibited by treatment of these cells with finasteride, an inhibitor of the enzyme producing 5alpha-reduced neurosteroids. In addition, HDAC inhibitors enhanced serotonin-stimulated BDNF gene expression, the enhancement of which could be abolished by the inhibition of 5alpha-reduced neurosteroid production in the glioma cells. These results suggest that HDAC inhibitors may be able to promote the differentiation of rat C6 glioma cells through the production of 5alpha-reduced neurosteroids, resulting in the enhancement of serotonin-stimulated BDNF gene expression as a consequence of promoting their differentiation, indicating the possibility that differentiated glial cells may be implicated in preserving the integrity of neural networks as well as improving the function of neuronal cells in the brain.

ncbi.nlm.nih.gov/pubmed/19360904

mariobros · May 25, 2018, 6:24am

Very interesting, i just ordered myself some sodium butyrate and will be giving it a try. I expect it will be the kind of thing that will take some time for any improvement to become apparent, however.

golf · May 25, 2018, 6:24am

please keep us updated. I am going to be asking my doctor about valproate on Tuesday.

anonnn1 · May 25, 2018, 6:24am

I just started taking sodium butyrate today…Took 3 tablets so far…I’ll update on any positive progress, don’t you worry…

m_81 · May 25, 2018, 6:24am

Could this explain why some people have been cured by taking SSRIs? Shippen himself sometimes prescribes SSRIs to post-fin sufferers, as reported here: http://www.propeciahelp.com/forum/viewtopic.php?f=3&t=1162&start=40

anonnn1 · May 25, 2018, 6:24am

I dont see how SSRI’s could fix us considering they are the cause of Erectile Dysfunction for people who actively take them. I know shippen prescribes low dose SSRI, but still it’s a risk I think…

kazman · May 25, 2018, 6:24am

Shippen uses extremely low doses, presumably because SSRIs at very low doses solely inhibit the breakdown of allopregnanalone, without altering seratonin reuptake. Allopregnanalone is synthesized from progesterone via 5 alpha reductase type 2, and certainly, given our low Adiol-G levels, we are not synthesizing as much allopregnanalone as we used to.