5ar1 negatively regulated by Testosterone and DHT.

#1

file:///C:/Users/public.AUD54606QN-L76/Downloads/Differential_regulation_of_steroid_5alpha-reductas%20(1).pdf

This is why I think a lot of us get worse when we try and increase Testosterone and DHT. And why a lot of experience some improvement when take a 5ar inhibitor. Decreasing DHT increases 5ar1 expression in the CNS

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#2

Weird because other studies showed that increasing DHT was upregulating 5AR1 but downregulating 5AR2