5ar1 negatively regulated by Testosterone and DHT.


This is why I think a lot of us get worse when we try and increase Testosterone and DHT. And why a lot of experience some improvement when take a 5ar inhibitor. Decreasing DHT increases 5ar1 expression in the CNS

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Weird because other studies showed that increasing DHT was upregulating 5AR1 but downregulating 5AR2

Could you share those studies?