5AR inhibition and synthesis

General Discussion
#1

Any input/insights would be appreciated…

There seems to be a distinction between steroidal and non-steroidal inhibition of 5AR, based on the fact that steroidal inhibition is irreversible (e.g. with fin), and non-steroidal inhibition (e.g. with zinc or Omega 3) is not.

If inhibition is irreversible, why do lots of people who take fin have no problems at all? That would seem to imply that the irreversibly inhibited 5AR is somehow metabolised away and new non-inhibited 5AR is produced in its place. But for us, I guess no new 5AR is produced (or produced at a much reduced rate).

I am trying to understand the process whereby steroidal enzymes such as 5AR are actually synthesized. For example, studies suggest that lifting weights increases expression of 5AR, and DHT also increases expression of 5AR, but exactly how does this happen? What are the biological mechanisms of 5AR synthesis and production?

Any references to available academic studies would be most welcome.

#2

It’s interesting that you are asking yourself these questions because I am currently asking my self the same questions.

So far I came up with only one possible avenue to investigate. This is vitamin b12.

Recently I started to go through some old blood labs that I had done which where the first set of labs I had done 3 months after pfs started for me. I noticed that my vitamin b12 levels where low.

This caused me to start researching vitamin b12 and learned that vitamin b12 plays an important role In Are body’s ability to produce new cells and DNA.

Is it possible that my body did not produce more of the 5 alpha reductase type 2 enzyme after taking a substance that destroyed it because I was low on vitamin b12?

Is there a possible link that we all share of having low or low normal vitamin b12 levels currently and or at the time we started having problems?

After all it’s not every day we take a drug that destroys a naturally occurring function in are body.

I plan on doing a new post under the theories section regarding this possible b12 connection.