Also posted this in the thread “Reversing silenced AR signal with demethylating agents - A promising treatment option?” link>http://www.propeciahelp.com/forum/viewtopic.php?f=5&t=3901&p=30415#p30415
Evidence that steroid 5alpha-reductase isozyme genes are differentially methylated in human lymphocytes.
The overall results suggest that 5alpha-reductase genes 1 and 2 are differentially methylated in lymphocytes from normal and 5alpha-reductase deficient patients. Moreover, the extensive cytosine methylation pattern observed in exon 4 of 5alpha-reductase 2 gene in deficient patients, points out to an increased rate of mutations in this gene.
ncbi.nlm.nih.gov/pubmed/11948017
Differential methylation in steroid 5 alpha-reductase isozyme genes in epididymis, testis, and liver of the adult rat.
Our results suggest that the differential methylation pattern in 5 alpha-reductase gene 2 in reproductive and nonreproductive tissues should be involved in the regulation of its expression.