5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis

General Discussion
#1

A few studies here, one was brought up in 2014.

5a-Reductase Type 1 (Avodart)
Deficiency or Inhibition
Predisposes to Insulin
Resistance, Hepatic Steatosis,
and Liver Fibrosis in Rodents

5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis.

Changes of metabolic profile in men treated for androgenetic alopecia with 1 mg finasteride.

Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study

Effect of finasteride on lipid profile in individuals with androgenetic alopecia

https://www.researchgate.net/publication/258859071_Effect_of_finasteride_on_lipid_profile_in_individuals_with_androgenetic_alopecia

edits arent updating

Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man

https://academic.oup.com/jcem/article/101/1/103/2806602

Long-term treatment with finasteride induces apoptosis and pathological changes in female mice

https://journals.sagepub.com/doi/abs/10.1177/0960327119842195

5-ARI may have adverse metabolic effects

https://www.urologytimes.com/modern-medicine-feature-articles/5-ari-may-have-adverse-metabolic-effects

1 Like
#2

Agree. I have seen these articles. I myself got fatty liver and gained weight during/after finasteride.

#3

Adding to or looking at some of these disease processes and how the line could become blurred.

Relationship Between Arterial Stiffness and Depression Mediated by Metabolic Syndrome, Inflammation

#4

I Thought this was interesting, or something to keep in mind.
If there was any type of abnormal vascular issues going on, maybe this could show up here first.

Pulse pressure, an index of arterial stiffness, is associated with androgen deficiency and impaired penile blood flow in men with ED.

#5

ritengo che la resistenza ai glucorticoidi possa avere un fondamento