Have any of you who have had the 23andMe test performed found you were a carrier of Cystic Fibrosis?
3/3 sufferers of Accutane related sexual dysfunction and depression were found to be a carrier of a Cystic Fibrosis mutation. There is only about a 1/15,000 chance of 3 random people all being carriers.
I spoke with the mother of a 4th Accutane victim who suffered from severe and long term depression who, without any prompting from me, mentioned that her son’s side effects were a bit better now, but he carries two different mutations of the CF gene and now suffers from complications of Cystic Fibrosis on top of Accutane side effects.
I know that 3 of us have the DeltaF508 mutation. I lost contact with one of the people who had the test done, but it is likely he also has the DeltaF508 mutation because it is the most common by far.
The chances of 4/4 randomly chosen people being carriers are somewhere around 1/400,000. It may be a coincidence, but seems like something worth looking into IMHO.
The mother of the fourth victim is also a doctor and has a bit of background in genetics. We were discussing how unlikely it would be that Cystic Fibrosis would have anything to do with side effects since the mutated copy of the gene is typically shut down when you have one good copy.
She mentioned the possibility that another gene which IS involved in development of side effects could be copied alongside the CF mutation.
This may be coincidence, the test may have been throwing false positives, this may be something effecting only retinoid (Accutane) metabolism and have nothing to do with PFS itself, or it may be significant.
Additionally, I should say there was one sufferer of Saw Palmetto side effects who said a CF mutation did not show up on his 23andMe test.
Also, if you did have the 23andMe test performed and found you WERE NOT a carrier of a CF mutation, could you say so please? That would also be a big help.