(WO/2008/054214) USE OF 3-ALPHA-ANDROSTANEDIOL, OPTIONALLY IN COMBINATION WITH A PDE5 INHIBITOR, IN THE TREATMENT OF SEXUAL DYSF

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#1

LINK:

wipo.int/pctdb/ja/ia.jsp?ia= … SPLAY=DESC

Very interesting…Experimental use of 3 adiol G with a drug like viagra…Read!

3-alpha-androstanediol is described in US 6,242,436 Bl as an alternative to androgen repletion therapy and for androgen decrease/depletion related problems in humans. The described purpose of this substitution lies in the replenishment of subphysiological serum concentrations of dihydrotestosterone (DHT) via 3-alpha-androstanediol administration. Also, the mechanism of effect of decreasing androgen decrease/depletion related problems lies in the replenishment of (DHT), according to US 6,242,436 Bl. Androgen depletion can decrease sexual motivation. However, decreased sexual motivation is often not caused by abnormal androgen concentrations.

For the treatment of male and/or female sexual disorder a number of different treatments, with greater or lesser degrees of success have been suggested and applied. For example, WO 2005/107810 describes the use of testosterone and a type 5 phosphodiesterase (PDE5) inhibitor which components must be released within a certain order and timeframe in respect of sexual activity. Although this treatment provides promising results, the used timeframes are considered to be undesirably long within the context of anticipation of sexual activity. Moreover, the treatment described in WO 2005/107810 is somewhat complicated because, depending on the formulation of the active ingredients, the active ingredients have to be administered within a certain order and/or timeframe. In persons who are not very accurate in taking the right active ingredients at the right time points, the goal of treating sexual dysfunction may not or only partially be reached.

The present invention discloses that 3-alpha-androstanediol administration induces increased sexual motivation and increased attention for sexual cues in men with MSD and women with FSD. These 3-alpha- androstanediol administration dependant increases in motivation and attention are independent of prior physiological androgen concentrations; 3- alpha-androstanediol administration will increase sexual motivation and attention for sexual cues in men and women with normal (i.e. physiological) or with subphysiological androgen levels alike.

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#2

I’m very surprised nobody commented on this study…It’s probably one of the bests I’ve posted…Please read the article fully…It’s a good one.

The scientists here are doing experiments on individuals with ED by administering viagra(10mg) and 3-diol G(.05 mg) Read Below.

If we can be part of a study of this magnitude, it could be extremely promising for us and even reopen an idea for a class action lawsuit.

READ!!!

Experiment 2 3-alpha-androstanediol and sildenafil in MSD efficacy of combined administration of 3-alpha-androstanediol and a PDE5 inhibitor —sildenafil- on male sexual function in response to erotic film excerpts in men with MSD

In a double-blind, randomly assigned placebo controlled cross-over design, a group of 16 men with male sexual dysfunction (MSD) will receive

  1. 3-alpha-androstanediol (0.5 mg) and sildenafil (10 mg)

  2. 3-alpha-androstanediol (0.5 mg) alone

  3. placebo on 3 separate experimental days.

According to the invention the level of free 3-alpha-androstanediol should preferably be a peak plasma level of at least of 10-100 times and preferably of 5-100 times the normal serum levels [4] (i.e. 0.6-6 and preferably 0.3-6 ng/1 for women and 2.2-22 and preferably 1.1-22 ng/1 for men), which will typically occur between 1 and 60 minutes after administration of the 3-alpha- androstanediol.

The penile tumescence and rigidity will be measured in response to neutral and erotic film audiovisual stimulation (VSTR), directly after drug administration, and 1 hour after drug administration, directly followed by measurement of vibrotactile stimulation ejaculatory latency time (VTS-ELT) and postejaculatory erectile refractory time. The three experimental days will be separated by (at least) a three- day period. On all drug administrations, subjects will receive one capsule consisting of either sildenafil, or a placebo, and one liquid formulation with either 3-alpha-androstanediol or placebo. Both capsule and liquid formulation will be taken at the same time, one hour prior to testing. The effect of sublingual 3-alpha-androstanediol and will overlap with high sildenafil serum concentrations (Tmax of sildenafil 30-120 min; Tl/2 = 3.5 hours). due to their similar time lag (0-1 hour).

The experiment will be preceded by a screening visit. In this screening visit subjects are interviewed and examined by a resident of the department of gynaecology of Flevo Hospital, Almere to diagnose for MSD and to determine eligibility for study participation. Subjects will be asked to fill out a questionnaire; the international index of erectile function questionnaire (IIEF). Weight, height, blood pressure (supine and standing) will be measured. Cardiovascular condition will be tested and ECG checked for significant abnormalities. Participants are required not to use alcohol or psychoactive drugs the evening before and the day of experimentation.

#3

This is interesting! How the fuck are they supplementing 3-adiol g?

#4

They are scientists and obviously can test it legally on subjects.

3-alpha-androstanediol was a legal supplement sold at vitamin shoppes about 8 years ago. it was banned and made a steroid from US markets. It is now used at experimental measures.

The FDA should be able to assist us or helping us out, but they do not care, nor does Merck care. I strongly believe this is the nature of our problem.

With more of my research, I’m learning proper adrenal functioning is important for proper 3-adiolg secretion.

#5

“With more of my research, I’m learning proper adrenal functioning is important for proper 3-adiolg secretion”. If this is true, than it should also be true that proper 3-adiolg secretion is important for proper adrenal function. I say this because everything in the body regarding to hormones work in loops. Secretion and feedback.
So maybe supplementing with 3 adiol g could improve adrenals as well.

#6

Yeah I agree…it may balance everything out…

#7

here is another link with the same study. Could not find contact info however.

freepatentsonline.com/EP1925307.html

Bloodwork for Dr. Alan Jacobs
#8

Kind of strange that none of these patents use the word “glucuronide” which I think refers to the actual enzyme produced when T is transformed to DHT via 5 alpha reductase Type 2 in the prostrate, pituitary, and other key organs.

Please correct me if I’m wrong.

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#9

Here is information on the applicant, a company called Emotional Brain B.V. of the Netherlands (in business since 1999). It would be worthwhile tracking down the presentation that was made in February (here is the reference in case Business Week update’s their site “Emotional Brain B.V. Presents at 3rd Annual European Life Science CEO Forum, Feb-12-2010 through Feb-12-2010. Venue: ConventionPoint, Selnaustrasse 30, Zurich CH-8021, Zurich, Switzerland” ).

investing.businessweek.com/resea … Id=4985430

Here is the company’s website, I wonder of any Dutch forum member could contact them?

emotionalbrain.nl/

Annon1, nice find indeed.

#10

Your welcome…Thanks for looking further into this as well…There are nights where I stay up all night and research research research until I can’t research anymore.

I want all of us to get better…trust me on that.

#11

This thread has a lot of measure. Let’s concentrate on this please.
Kazman, I believe ‘glucuronide’ is added as the waste product in the blood to the ‘3 alpha androstanediol’

JN