I find this all very interesting. I don’t know my full 23andme panel yet but I know I have low COMT activity. The COMT enzyme is responsible for metabolizing estrogen via methylation, as well as neurotransmitters. This would be neuro-estrogen as @moonman1 points out.
I also have the cyp1b1 which has to do with estrogen if I understand correctly as well
Interestingly, in the revival of this topic, I looked up Methylation, and a site the made some recommendations to overcome demethylation, they seemed incredibly similar to the suggestions others had to improve PFS symptoms.
At this point, the advice doesn’t seem to hurt, but without additional serious science and research, it doesn’t bring us closer to understanding root cause or a remedy.