Why test for 3a-diol-G and what to do based on the results?

General Discussion
#1

mostly what to know what to tell the endro regarding the 3a-diol-G. I took it upon myself to handwrite it on my endros labreq after learning the code from the lab. If he makes a federal case about it when I go in I would like to explain what my course of action will be if I am out-of-range. I lose alot of credibility with doctors when I start talking about FIN sides and 3 have told me they are on it themselves (so I guess my speal hits close to home).

My lab results have varied over the last couple of years especially on HRT but low available T and low thyroid and high estradol seem like the trend.
DHT became normal after stopping FIN and my anemia went away then also.

I know need to post my story - but long story short i had many of the same symptoms as all of you which co-incided with stopping FIN.To make it worse I stopped started several times. I happen to be middle aged so of course my symptoms have been attributed to this by most doctors. I have been to GP, 2 urologists, 2 endros and anti-aging doctor.

The only thing everyon can agree on is low Thyroid (T3 and T4) and Hydrocele and varicocele (one of each which is “nothing to worry about” per urologist). Also: glucose is high so that might account for some fatigue (pre diabetic?)

anti aging doctor protocole was T + HCG + HGH + Crysone + Thyroid.

Allthough this made me feel good, I had some issues with it (which ill post in my story later) Crysin failed to reduce estridol levels and at one point I was as high as 102. Novadex (tamoxofin) made me feel good but made it impossible to achieve orgasm so I stopped it.

I am currently weened off everything and have opted for ordinary pharmaceutical company thyroid meds (cytomel & sytharoid) and this has fixed the fatigue and depression.

I get more labwork next week for the first time since weaning off HRT so I am interested in the results. Libido is still not where it used to be allthough the functionality is there.

I will post lab results and my story later this week.

but mostly what to know what to tell the endro regarding the 3a-diol-G

I am intersted in natural T boosters and natural estrigne inhibitors but am wanting to see if I can get thru this without any more boiidentical stuff or meds. I am going to try to gradually reduce the Thyroid meds if the las results are otherwise ok and see how low i can go or if my bodys T3 & T4 will gradually come back.

#2

Adiol-G info.

propeciahelp.com/forum/viewtopic.php?t=761

Basically it can be interpreted as a marker for intracellular 5AR2 activity. It is also a marker for cutaneous androgen activity (skin). 3a-diol-G is documented to be reduced by Finasteride, because it is a metabolite of DHT.

Considering a lot of guys have yet to recover after taking/quitting Fin, has led to speculation that perhaps 5AR2 or Adiol-G was damaged.

Numerous guys have wound up with low Adiol-G levels, but we have no baseline to compare against. Still, there appears to be a trend here.
propeciahelp.com/forum/viewtopic.php?t=2763

The other possibility is the enzyme 3a-HSD, which metabolizes DHT to 3a-diol-G, has been damaged as a result of Fin use. Ask your endo about these pathways, maybe he can provide insight: propeciahelp.com/forum/viewtopic.php?t=518

As for what to do if you have low results… well, that’s the million dollar question. Hence why some guys are trying TRT, DHT (creams/injections) and other treatments to see if it increases Adiol-G levels, or makes any difference in symptoms.

#3

I print off the AdiolG results to show the endocrinologist.
Also, there is a post which indicates NORMAL AdiolG results for NORMAL men. I believe the range commonly quoted includes the hermaphroditic range.

DHT supplementation works for me, particularly Proviron and Masteron.
Interestingly, but unfortunately, ANDRACTIM (DHT gel) does not have the desired effect on us men, despite scientific literature stating that both serum DHT and DHT metabolites are adequately raised.

Why is this???

I theorise that Andractim has too much of a topical (local effect) where the gel is applied, increasing the LOCAL DHT metabolites. Men of ‘penis extension’ forum apply gel locally to penis. Men of ‘gynaecomastia’ forum apply gel locally to breast tissue. Even men of ‘bearded’ forums, who want stronger facial hair growth, apply gel locally.

I believe there is a disproportionate LOCAL elevation of DHT metabolites with Andractim gel. I believe the LOCAL skin’s (where it is applied) 3HSD enzyme system could be metabolising DHT gel before it properly gets into the system.

For me, Andractim at 10g per day holds my mood up a bit, does slightly help with erections and even prostate issues.

I believe IM DHT is a better delivery mechanism.

JN

#4

I commend you! Good work.

JN

#5

The same happened to me. When i went to the dermatologist to talk about hairloss for the first time, he told me he (the doctor) had been taking propecia for 5 years then, and had no side effects at all. This was a big influence in taking propecia for me, i thought “if nothing happened to him…” Today i highly doubt it he had no sides. People lie so much about sex. They carry on in failed marriages just for convention. Too bad i was so young and naive. I give you credit for having 3 adiol g tested against your dr s will.

#6

Too right Corrievip,

The number of silent sufferers must be enormous. If you are reading this now, and you are a silent sufferer, come forward and register as a user on this forum.

Furthermore, please enrol in the following study conducted by Dr Irwig at George Washington University.

propeciahelp.com/forum/viewt … sc&start=0

Every case counts, makes our suffering more statistically significant, and will lead to treatment.

JN