I also had brain fog for a couple of years (I was not even able to tell what I had for dinner the day before…). I am much better now. But the physical problem remains.
In any case, nobody knows exactly what is happening on the physical level either, and no matter how much I insist to urologist and even to people in this forum, nobody seems to care about this issue, and I think they are overlooking something important here.
Totally agree, especially for me everything startet with ed then shrinkage and somehow later the anxiety/depressive issues. I can tolerate anything but the damage of my sexual organs. I don’t understand why there is only little research in that issue. I can’t think about injecting me stuff into my penis or take ed pills above 37,5mg of sildenafil otherwise I get heart palpitations but there is only little effect in that dosage. One time I had to go to the Emergency Room because I took 50mg of sildenafil I thought I had an heart attack. I don’t want to die at least not yet and especially not because of ED pills.
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Did you try low dose Tadalafil? (5mg, at least 6 months).
Even if you don’t have erections, Tadalafil is working to improve blood flow.
Also, did you try vacuum device? After 3 months of daily (proper) use, it can help rehabilitation.
Not yet but I will (tadalafil). But I doubt that I will get the results I’m expecting, I also have tinnitus because of Sildenafil. But it is tolerable.
Why you want getting mechanical erections with drugs?
…Because that is the only way some of us can get erections. It’s not something anyone prefers.
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why would there be serious penile tissue research? I have PFS and almost no penile issues
That’s what I thought in the first 1 or 2 years (everything looked normal, although the erection process was impaired).
Then after 2 years it became apparent that there was something wrong in the tissues. My flaccid penis has an hourglass shape, as if the blood didn’t flow normally from proximal part to distal part. It looks like peyronie but it is not exactly that (because peyronie should appear in erect penis, not in flaccid penis)
my erection process isnt impaired
my dick looks the same as before.
ive had this for like 5 years now. only mental symptoms, like plenty of others.
PFS has to do with dna methylation not just penis tissues only
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my erection process isnt impaired
my dick looks the same as before.
Then you can consider yourself very lucky
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if i had a chance to trade my dick for my brain, id do it in a heartbeat, so i dont know about lucky
the point is, this isnt a penis only issue at the root
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Why did you use finasteride to artificially keep your hair? 
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Oh, be careful what you wish for.
An interesting thing to note is upon further delving into the study, it seems like the control group had never taken Finasteride. Perhaps permanent upregulation of AR is just a function of taking a 5-ar inhibitor and isn’t necessarily indicative of PFS per se. By that I mean Finasteride users how stopped taking the drug but didn’t suffer from PFS may also exhibit upregulation of AR.
In fact I’ve read studies that purport that AR upregulation is part and parcel of androgen deprivation therapy - much of the research has focussed on the prostates and prostate cancer, naturally. For instance:
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