I visited today. The doctor admitted that I know more about her and that she does not know anything about it and has never heard or seen anything like it. He said that my situation is tragic and he does not know how to help me… He knew nothing about the syndrome!..
The exams all in the norm!
But, she suspects the thyroid. Can there be a possibility?
Does the OXERUTINE DESTROY THE THYROID?
Apparently yes. There is a possibility, even if I believe it to be unconvincing, that the thyroid has completely left and therefore that all the problems I have are due to that. Having not yet done the tests, it is hoped that this is the cause.
First of all, I discovered that Thyroid modulates Androgens (AR) and Testosterone but also estrogens.
"The present data suggest that T3 down-regulates ERs and up-regulates ARs in peripuberal Sertoli cells. The additive effect of testosterone and T3 in up-regulating ARs could possibly involve a role for T3 in influencing the androgem" (Wilson CM, Griffin JE, Reynolds RC, Wilson JD. The interaction of androgen and thyroid hormones in the submandibular gland of the genetically hypothyroid (hyt/hyt) mouse. Endocrinology. 1985 Jun;116(6):2568-77. https://www.ncbi.nlm.nih.gov/pubmed/8568470
Also Dihydrotestosterone
"We have shown previously that T4 acts synergistically with 5 alpha-dihydrotestosterone (DHT)"
(Wilson CM, Griffin JE, Reynolds RC, Wilson JD. The interaction of androgen and thyroid hormones in the submandibular gland of the genetically hypothyroid (hyt/hyt) mouse. Endocrinology. 1985 Jun;116(6):2568-77. [https://www.ncbi.nlm.nih.gov/pubmed/3888614]
Here it is written that quercetin destroys the thyroid!
"Quercetin is the most abundant flavonoid present in a broad range of fruit and vegetables. Furthermore, quercetin is available as dietary supplements that are based on its antioxidant, antiproliferative and anti-inflammatory properties. However, concerns have been raised about the potential toxic effects of excessive intake of quercetin, and several studies have demonstrated that flavonoids, included quercetin, can interfere with thyroid function. In a previous report, we showed that quercetin inhibits thyroid-cell growth and iodide uptake. The latter effect was associated with down-regulation of sodium/iodide symporter gene expression. In the present study, we have evaluated the effects of quercetin on the expression of other thyroid-restricted genes, and we show that quercetin decreases the expression of the thyrotropin receptor, thyroid peroxidase and thyroglobulin genes. We further investigated the inhibitory effects of quercetin on thyroid function in vivo through evaluation of radioiodine uptake in the Sprague-Dawley rat, which was significantly decreased after 14 days of quercetin treatment. These data confirm that quercetin can act as a thyroid disruptor, and they suggest that caution is needed in its supplemental and therapeutic use." (Giuliani C, Bucci I, Di Santo S, Rossi C, Grassadonia A, Piantelli M, Monaco F, Napolitano G. The flavonoid quercetin inhibits thyroid-restricted genes expression and thyroid function. Food Chem Toxicol. 2014 Apr;66:23-9. doi: 10.1016/j.fct.2014.01.016. Epub 2014 Jan 18. https://www.ncbi.nlm.nih.gov/pubmed/24447974)
"Quercetin acts as a rat thyroid disruptor with anti-thyroid properties both in vitro and in vivo. Quercetin decreases the expression of the thyroid-restricted genes, NIS, TSHR, TPO and TG in FRTL-5 thyroid cells. The administration of quercetin (50 mg/kg) for 14 days reduced thyroid radioiodine uptake in Sprague–Dawley rats." https://www.sciencedirect.com/science/article/pii/S0278691514000301?via%3Dihub (IBidem)
At this point we must hope that something comes out of the thyroid, if this were the cause we could cure and consequently solve everything. It is written that destroys it in the gene! In your opinion, can the typhoid give these symptoms so serious? I have all the anesthetized body and total impotence and all the symptoms of Finasteride syndrome! Maybe there is also Vitamin D that has been inhibited by it.?..
That substance Quercitin is anyway inhibits 5 alpha reductase.
We’ll see…
