Other than it made you worse this is good info. As far as trying Allopregnanolone goes using Brexanolone sounds like the best option. It’s an infusion and must be giving under doctors supervision. I’m about the cause but even if we could get our hands on this giving ourself an infusion over a three day period does not sound practical. This will require a doctor’s order and supervision.
Is it your understanding that the only difference between SAGE-217 and Allopregnanolone that Allopregnanolone can covert back to 5a-DHP? No difference in how it can effect us?
You could order 5a-DHP which a handful of us including my self have tried with limited results.
5a-DHP converts to Allopregnanolone via 3a-Hydroxysteroid dehydrogenase (3a-HSD). This enzyme can also convert Allopregnanolone back into 5a-DHP.
You could try taking 5a-DHP. But in my opinion unless we are low in either 5a-DHP or Allopregnanolone it wont help and we are more likely to get worse from it. We need members to get tested for Allopregnanolone. I am looking for a way that we can get tested for it. In one of the Neuroactive steroid levels studies 5a-DHP was low in the CFS of the PFS group and in the other study 5a-DHP was low in plasma. So clearly 5a-DHP and possible issue with 5a-DHP converting to Allopregnanolone is something of interest for us but we really need to get tested for these things. It’s clear from some of the other forums that there are different cases of PFS. If I had to guess it’s probable because we took drugs that bind NADPH which 5AR and other enzymes in the hormonal pathway need to work. So we all probable ended up with different enzyme disorders causing similar symptoms. So there will never be a one size fits all solution. We really need to get our own testing down and figure out which enzymes are causing our own imbalances so that we can start figuring out what exactly our malfunction is.