Of course it does that. Too much of any hormone downregulates the receptors for it. If people have low progesterone then there’s definitely nothing wrong with progesterone converting to allopregnanolone and 5ar2 is functioning perfectly in the brain. You have already understood that probably and are looking for a more indirect cause, right?
ncbi.nlm.nih.gov/pubmed/20486040
Ok, I finally found something. The neurons they are investigating are the same allopregnanolone producing pyramidal neurons in the hippocampus.
lf1.cuni.cz/Data/Files/Pragu … 9a0025.pdf
Does anybody know, if there’s a similar study done on 1 mg? I think that would be enough to go to court.
livestrong.com/article/12864 … gesterone/
Progesterone is a hormone essential to sexual health. Progesterone regulates menstruation and breast development, plays a role in female fertility and performs a range of functions in other tissues. Progesterone is produced in the adrenal glands and ovaries, as well as in the placenta during pregnancy. The body tightly regulates progesterone levels, and low levels of progesterone can lead to a deleterious effects.
Depression
Progesterone plays a natural role in regulating mood owing to its effect on a chemical called serotonin. Serotinin is a neurotransmitter—a protein found in the brain that facilitates signaling between nerve cells. Too little serotonin leads to mood disturbances and depression. The Oregon Health and Science University, or OHSU, reports that low levels of progesterone are associated with low levels of serotonin in the brain, so low progesterone levels can lead to depression.
Dr. Cynthia Bethea at OHSU explains that progesterone leads to the production of more serotonin the brain, increasing the overall levels of serotonin. Progesterone also promotes the survival of brain cells that respond to serotonin, increasing serotonin signaling to fight depression further. Patients with low progesterone levels may experience depression related to the loss of these depression-fighting mechanisms.
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Read more: livestrong.com/article/12864 … z2FAv36reb
Sexual Dysfunction
Low progesterone levels may also lead to sexual dysfunction. Progesterone, along with several other hormones, plays a role in facilitating female sexual function, so the loss of progesterone is often accompanied by sexual symptoms. A 2004 study published in the “Journal of Sexual Medicine” indicates that a loss of sex hormones such as progesterone can lead to decreased sex drive, pain during sex and difficulty achieving orgasm. Low progesterone also plays a role in erectile dysfunction in men. Hormone therapy to supplement levels of progesterone can alleviate the sexual symptoms associated with low progesterone levels.
Read more: livestrong.com/article/12864 … z2FAv5oNTA
livestrong.com/article/47760 … en-in-men/
Low Progesterone Levels
As men age, testosterone levels decline and estrogen levels start to rise. Progesterone levels in men drop sharply as estrogen levels climb, causing symptoms such as low libido, hair loss, weight gain, fatigue, depression, gynecomastia – enlarged breasts – erectile dysfunction, impotence, bone loss and muscle loss. Aside from this, men who have low levels of progesterone have a greater risk of developing serious illnesses such as osteoporosis, arthritis, prostatitis and prostate cancer.
Read more: livestrong.com/article/47760 … z2FAvNQhkO
Yup!!! Bit will be our savior…not kidding
One interesting thing i found was…that progesterone plays a huge role on neuroprotection and myelin repair…and i have been using cerebrolysin and helped my sensitivity for a few days…now its just as bad as it was before. I am starting to think this can really help us!!
some people claim benefits. others don’t. i have yet to feel anything.
have you performed a search for progesterone? there’s comments about it dating back years.
livestrong.com/article/31812 … ne-in-men/
Progesterone is a hormone that is usually associated with females. However, it is essential in both sexes. In men it is mainly produced by the testes and is required for such vital bodily functions as development of bone density and regulating blood sugar levels. In men, progesterone is converted to testosterone. When a man has low progesterone levels his testosterone levels will also be low. There are several symptoms to be aware of if you suspect your progesterone levels are low.
Fractures
Men with low progesterone levels may be more prone to fractures due to reduced bone density that can lead to osteoporosis. Men over age 50 are more at risk of developing osteoporosis, which affects more than 2 million men in the United States. Low progesterone levels in men are one of the causes of low bone density.
Reduced Libido
Reduced libido or loss of sex drive is a common symptom of low progesterone in men. This may lead to loss of interest or desire for sexual activity. Another feature of reduced libido is erectile dysfunction. This occurs when a man has difficulty achieving or maintaining an erection. A man experiencing reduced libido may also have low mood, increased stress levels or depression.
Depression
Common symptoms of depression include low mood and loss of interest in daily activities that you used to enjoy. You may also experience early morning awakening. This happens when you wake up in the early hours of the morning, usually 3 or 4 a.m. and are unable to get back to sleep. More severe symptoms of depression include thoughts of self-harm or suicide.
Body Fat
One of the functions of progesterone is to protect the body against high levels of estrogen. Low progesterone levels create a hormonal imbalance that leads to estrogen dominance. This is when the body produces more estrogen than it requires. Symptoms of estrogen dominance in men include an increase in abdominal fat and development of fatty tissue in the chest area. There can be a reduction in facial hair and low levels of energy leading to exhaustion and fatigue. A man with low progesterone levels and estrogen dominance may notice an increase in the frequency of urination and may also be at an increased risk of developing a heart condition.
Ring a bell??
Ive got a very bad case of frequent urination. Also my facial hair does not grow at the normal rate while I dont have any major depression I have very little interest in daily activities.
Another thing that use to happen to me is that I would instantly wake up in the middle of the night.
what is your vasseporsin level
No idea, is vasseporsin normally included in a standard blood test ?
For those who are interested:
onlinelibrary.wiley.com/doi/10.1 … ated=false
You can buy it as normast from Germany if you so desire. Tried in past to no success.
1 Like
ncbi.nlm.nih.gov/pmc/articles/PMC3100179/
Interesting to note increasing testosterone has negative effects on allopregnanolone.
Testosterone-induced aggression is associated with a decrease in brain expression of the rate-limiting step enzyme in allopregnanolone biosynthesis (i.e. 5α-reductase-type-I) and in brain allopregnanolone content.
I believe allopregnanolone certainly plays a role in the mental side effects however I am not convinced it is the explanation for all the sexual ones. Only research can tell.
1 Like
Do plasma progesterone levels rise while taking finasteride? Any studies on this?
ncbi.nlm.nih.gov/pubmed/20486040
This says perfectly that allopregnanolone levels return to normal as neurogenesis becomes the same again after finasteride usage. If there happened some real neuron death, I think somebody would have noticed this already. There are plenty of studies out already done on fin and brain.
And toxicologists must test drugs on different most typical cell types (neurons, cardiac muscle cells, hepatocytes and so on) before they allow it to be studied any further, do they, right?!
Has anyone else experimented with normast/peapure (Palmitoylethanolamide)?
It increases allopregnanolone:
ncbi.nlm.nih.gov/pubmed/21554431
ncbi.nlm.nih.gov/pubmed/19864116
I have taken it at a low dose before without much effect (in fact a slight increase of brain fog happened). I took a larger dose a few nights ago with a little alcohol (as this increases allo too) and had some positive results. Too early to say anything in more detail as a one off doesn’t prove anything.
If anyone wants to try it:
Allopregnanolone and THDOC have anxiolytic, anticonvulsant and sedative effects. In my opinion this can truly be linked to the sexual sides and other conditions such as muscle twitches. I would’t link it to everything tough: as an example, reduced semen etc in fact is a problem that even non pfs sufferers have, with no side effects. That appears to be the effect of the extreme action of finasteride on the prostate and the prostate apparently requires some good time to “rebuild”. However, low pogesterone/estrogen dominance can lead to chronic abacterial prostatitis, and this in turn can lead also to semen abnormalities.
I translate this form an italian book
books.google.it/books?id=LcMAy1x … ne&f=false
My concern is: how exactly can this lead to pudendal neuropathy? Actually I started having tinglings and contraction on pelvic floor only while using DHT gel for gynecomastia (which didn’t go away (progesterone?)). What happened is beyond my comprehension.
So are you saying that the lack of allopregnanolone can explain the way our sexual organs feel as well?
I think probably, in conjunction with affected progesterone and THDOC. However I think it is somewhat complicated and probably our ability to explain this entirely is not enough. I think Dr Traish and the other Researchers are on the definitve track. Also
ncbi.nlm.nih.gov/pmc/articles/PMC3356145/
Notice the first author, then look at the researchers that are going to discuss in February. Melcangi apparently has some competence in this field.
It depends on where and to what extent allopreganolone and progesterone have been affected. Probably, following the diagnoses of pundendal neuropathy (6 out of 6) in viewtopic.php?f=27&t=5661
, these affected values will lead to inflammation of the pundendal nerve in varying positions and to different extents, by MAYBE compression/inflammation in the pelvic muscles as said in the aforementioned thread. Progesterone is in the bloodstream and 5a reductase is expressed peripherically too in androgen dependant tissues. This means there is some good chance that some neurosteroids are affected peripherically. Here too, it depends on the peripheral expression of the three different 5areductase enzymes. I can’t explain precisely the phenomenon(requires extensive research). I think there is enough evidence that pfs is, in most part, inflammatory driven and there is also enough material to work on the possibility that neurosteroids are primary players (and might be the first players) also on sexual sides, centrally and peripherally. In encourage to take the progesterone tests so we can have a pool of data. I question myself if serum allopregnanolone is of significance and we might take this analysis.
Please take this as an opinion because this is somewhat complicated. Have to leave you
PS, numbness of the penis tells much probably this is a nervous condition. Androgen receptor overexpression and related signaling has something to do with nervers: I saw a study on rats where normal AR expression was restored by electrical discharges.
Yes i am starting to think the balance of allopregnanolone and other neurosteroids plays a part in the prostatic picture.
For example alcohol reduces testosterone and increases allopregnanolone. Quite a few people after a heavy drinking night have short lived improvements in sexual function the next day. Or with drugs.
Increasing testosterone ( i did this via tribulus - large dose - noted stronger erections, stronger libido), also made my brain fog much worse, i couldn’t get out of bed, my vision went worse and my prostate pain became unbearable. Testosterone reduces allopregnanolone. I often feel its the prostatic discomfort that affects my ability to get erections. I think the anti-inflammatory effect of doxycycline explains why antibiotics can be helpful.
Perhaps the overexpressed androgen receptor is therefore reducing the systemic content of allopregnanolone and stopping it from doing its job.
If so we need to understand by what mechanism is the AR overexpressed? How exactly the balance of neurosteroids in our bodies is balanced? And then what post translational modification explains the reduced overall androgen picture with which we suffer - which includes affecting the neurosteroid angle?
Of course we also have to consider what allopreg and neurosteroids bind to - GABA A.
I encourage people to let us know what effects alcohol, progesterone and PEA have had on you.