Tachyphylaxis or 'why we crash when we stop'

[Oscar]

Tachyphylaxis is a medical term describing ‘A rapid decrease in the response to a drug after repeated doses over a short period of time’. Increasing the dose of the drug will not increase the pharmacological response. Tachyphylaxis may develop with an initial dose. This can sometimes be caused by depletion or marked reduction of the amount of neurotransmitter responsible for creating the drug’s effect. Examples: Amphetamine, ephedrine (indirectly acting drugs)

Tachyphylaxis is a phenomenon which is characterized by the rate sensitivity: the response of the system depends on the rate with which a stimulus is presented. Specifically, a high intensity prolonged stimulus or often repeated stimulus may bring about a diminished response also known as desensitization.

en.wikipedia.org/wiki/Tachyphylaxis

A possible explanation to how we became immune to Androgens when DHT returns full force, but how to reverse this??

[toadstool]

@Oscar

Tachyphylaxis is a medical term describing ‘A rapid decrease in the response to a drug after repeated doses over a short period of time’. Increasing the dose of the drug will not increase the pharmacological response. Tachyphylaxis may develop with an initial dose. This can sometimes be caused by depletion or marked reduction of the amount of neurotransmitter responsible for creating the drug’s effect. Examples: Amphetamine, ephedrine (indirectly acting drugs)

Tachyphylaxis is a phenomenon which is characterized by the rate sensitivity: the response of the system depends on the rate with which a stimulus is presented. Specifically, a high intensity prolonged stimulus or often repeated stimulus may bring about a diminished response also known as desensitization.

en.wikipedia.org/wiki/Tachyphylaxis

A possible explanation to how we became immune to Androgens when DHT returns full force, but how to reverse this??

we are no immune to androgens…sigh…

[Oscar]

Sorry, toadstool. I meant: is this is how our respone to Androgens becomes downregulated? The answer would seem to be yes. I think this would be the technical term that fits in with awors theory. Which is useful when trying to find a cure.

1. We take fin.
2. Reduce DHT by 70%.
3. Stop taking fin.
4. Result is 300% increase in DHT on Androgen receptors (and reversal of sides for about 2 weeks)
5. Leads to Tachyphylaxis or receptor downregulation to androgens after stopping fin. Despite normal hormone levels.

[tim1911]

@Oscar

1. We take fin.
2. Reduce DHT by 70%.
3. Stop taking fin.
4. Result is 300% increase in DHT on Androgen receptors (and reversal of sides for about 2 weeks)
5. Leads to Tachyphylaxis or receptor downregulation to androgens after stopping fin. Despite normal hormone levels.

This is not the way it happened for everyone here oscar

[toadstool]

@tim1911983

@Oscar

1. We take fin.
2. Reduce DHT by 70%.
3. Stop taking fin.
4. Result is 300% increase in DHT on Androgen receptors (and reversal of sides for about 2 weeks)
5. Leads to Tachyphylaxis or receptor downregulation to androgens after stopping fin. Despite normal hormone levels.

This is not the way it happened for everyone here oscar

exactly, with myself, I never had a crash… quit the drug and the sides just stayed with me…

[bostonusa2009]

@Oscar

Sorry, toadstool. I meant: is this is how our respone to Androgens becomes downregulated? The answer would seem to be yes. I think this would be the technical term that fits in with awors theory. Which is useful when trying to find a cure.

1. We take fin.
2. Reduce DHT by 70%.
3. Stop taking fin.
4. Result is 300% increase in DHT on Androgen receptors (and reversal of sides for about 2 weeks)
5. Leads to Tachyphylaxis or receptor downregulation to androgens after stopping fin. Despite normal hormone levels.

I did experience the classic crash like many here when they quite, but you mention “Despite normal hormone levels”. Who has normal hormone levels here? Most of the blood panels I have seen have at least a couple of key hormones out of wack.