Yeah I also got PSSD months after quitting the drugs. It first was withdrawal and really after withdrawal, I got it full blown. My PSSD wasnt full blown in the first 8 months. It started gradual, and it ended in the total emptiness. The more withdrawal lessened, the more PSSD took over. As if my body worked from withdrawal towards PSSD as the new homeostasis, not to myself.
Hey everyone I talked with the guy in the article that has contacts in China and CRISPR doesn’t seem plausible right now but he did say that adenovirus treatment seems to be the treatment of choice not sure how this treatment would fit in with this condition as I haven’t researched it enough.
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Talked to phil and he said he will be hearing from Baylor in October but doesnt know when it will be published. Remember, this is part 1 of a study that was announced in 2013. It gives you an idea of how quickly things progress or do not progress!
This is one of thousands of examples that in the real world things are complex and thus move slowly. Maybe not always if you apply old technology on known problems but certainly when you are talking about developing cures for complex diseases or similarly challenging stuff (ex. autonomous vehicles, replacing fossil fuels with alternative energy sources like nuclear etc.). All this stuff takes time! Lots of time! We are not talking about developing a new app or other silicon valley type stuff.
Anyone who thinks CRISPR will solve most of this within the decade is making the same mistake that google made when it thought it could quickly make cars drive autonomously. They were projecting their experiences in the software world onto the real world, which is orders of magnitudes more quirky and complex. Many people involved in the autonomous car field have since admitted that they underestimated the scope of the problem.
Of course anyone is free to believe in a ray kurzweilesque fantasy.
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Talked to phil and he said he will be hearing from Baylor in October
So that means they will say Howdy! Maybe they will publish it in November for Thanksgiving and send the foundation a big ol Turkey leg!
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So why do you waste your time visiting this site? After all these years, just looking for for people to give you support?
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I like to keep up to date on the latest developments.
Wouldn’t it make more sense to check back every 10 years given your 25-50 year outlook?
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That outlook is for a cure. There are lots of step between “no idea what the hell is going on” to “we have a cure”. First steps is making some more significant finding with a comprehensive study like baylor. Then you need more studies to expand on the finding. Etc. etc…
Of course you are right that I could check in every 12 month to save my time.
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Makes sense. What’s your most bothersome symptom?
The rest period is just two weeks, since the half life of Dutasteride is 4-5 weeks, don’t you think it’s more likely it’s because of the drug still being in the rats’ systems?
A reason for this is that research is being done in the US where:
- It’s more expensive. You get less manpower for the amount of money you put in compared to other parts of the world like developing countries.
- The processes such as peer review, etc. are more comprehensive and as a result would take more time than it would were it to be done outside.
I guess the reason they chose to do these studies there was because when it was to publish, it would have more credibility than a study down outside.
Also, I think it is worth mentioning that patient recruitment took much longer than it needed to, and most of that part is on us.
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Honestly I think we all should push our existing options as far as we can, at least until we come up with better ones. I don’t disagree with other members on this thread who state that PFS is a complex problem and will take a while to solve, but I do not agree with their timeline at all. Did any of you, when smart phones came out, expect to be able to use it as a replacement for a DSLR camera, a walkman, your credit card, a library, a personal assistant, a fitness and sleep tracker or a gaming device more powerful than the standard console? That took place over the course of 10 or so years.
To me, CRISPR looks like the next big thing. It’s got tremendous potential that is being realized very quickly. I think it will be what fixes us, much sooner than 50 years. I don’t think any of the people investing hundreds of millions to billions of dollars in CRISPR based therapeutics are expecting to get their returns in 50 or even 20 years lol. The only thing we need to be concerned about is the etiology of this disease, which is probably quite complex, but I speculate recent advances in biology such as this one (https://www.synthego.com/applications/disease-models), will mean this process will also be expedited. If things go the way they’re going, the tools they’re using for studies right now will look like Nokias did when the iPhone came out in 2007.
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Not sure CRISPR could be used on already grown life organisms - it seems to be way too dangerous.
- Need to target specific region precisely without taegetting any other region of DNA
- Need to make it in each cell of the organism.
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It is being used to treat certain diseases in humans currently. Trials are going on.
The Duke team used a class 1 CRISPR system to edit the epigenome in cells. In a study published in Nature Biotechnology, they reported that they were able to attach gene activators to the Cascade complex and regulate levels of gene expression in cells. They also connected a repressor to Cascade to turn genes off altogether.
This seems good for us 
The potential of CRISPR is certainly there. Figuring out PFS worries me more than CRISPR being a flop.
Being realistic though, this will take a loooong time:
“We know CRISPR could have a big impact on human health,” said Charles Gersbach, Ph.D., Duke professor of biomedical engineering. "But we’re still at the very beginning of understanding how CRISPR is going to be used, what it can do, and what systems are available to us.”
We gotta take control of our own destinies to the best of our abilities in the meantime. I for one ain’t sitting for 20-30 years like a duck
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Thank you for the article, mate.
‘‘We gotta take control of our own destinies to the best of our abilities in the meantime. I for one ain’t sitting for 20-30 years like a duck’’ - fill out the survey please. No offense 
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Again, that progress is strictly limited to computers and software. Basically Moores Law, i.e. the observation that the number of transistors in a dense integrated circuit doubles about every two years (wiki).
In the real world nothing is progressing at the rate of Moores Law. Basically everything else is moving at a slow pace (1-2% improvement/ year). Otherwise our economy would be exploding with growth of 20% year.
Some examples of improvement rates from the real world:
energy density of batteries: about 2-3% per year
passenger car efficiency (between 1973-2017): 2.5% per year
indoor lightining efficacy: 2.6% per year
speed of intercontinental travel stopped improving in 1958 before that: 5.6% per year
energy intensity of steel from 1958 onwards: -1.7% per year
energy intensity of NH3 between 1913 and 2017: -2.9% per year
Crop yield increase between 1948 and 2011: 1.49% per year
Life expectancy increases 3 years every 25 years (however pace has slowed).
Nixon declared war on cancer in 1973.
On Alzheimers:
But in many ways—indeed some of the most important ways—the situation has not changed much. Alzheimer’s disease is still a plague upon us, and we don’t really know what to do about it. Decades of research and tens of billions of dollars have produced mountains of scientific and medical literature. Yet only marginally effective preventive or therapeutic interventions have resulted.
And on and on and on…
In medicine and basically all other industries in the real world, things progress at a slow pace not Moores Law pace.
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How far back are you looking? 1900 life expectancy was 47. Sometimes there are advances in technology that shift the paradigm. Technology advances are not not linear. Not too long ago diabetes was a death sentence.
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Thats the rate of improvement over the last two decades or so. Shockingly enough life expectancy in the US is currently decreasing:
I know. The above rates of improvement is of course the average rate. It includes breakthroughs. However even with a breakthrough the rate over time is only 2-3% for most industries. And in medicine most major diseases are not solved despite huge funding (alzheimer, cancer, mental diseases).
We have to be realistic, of course I also once hoped that PFS research will be the exception to the rule of slow progress, but if anything it will be even slower than average since it has no funding.
“We gotta take control of our own destinies to the best of our abilities in the meantime. I for one ain’t sitting around for 20-30 years like a duck.”
That’s because you have a minor case. Concerned about morning wood, a little lowered libido, and doing squats. You can still have sex and have a brain that works. You can wait 20-30 years. Some of us can’t and wouldn’t want to.
Also they still can’t get CRISPR into the human brain and aren’t sure how they ever will be able to. Even if they can it’s no sure thing they can fix a faulty gene in a grown human. You need a similar healthy cell to create it from.
Also the human brain is faaar from being understood by any doctor or scientist.
But other than that sound promising.
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