Successful puberty for a PFS-fathered son?

General Discussion
#1

I’m in my 8th year of PFS and one of my biggest fears is not ever becoming a father.

I’m getting scared that it might be getting too late to have a child.

I’m also gravely concerned about whether I should risk attempting to father a child in this PFS-compromised state, with low hormones, low androgens, still, impaired health. What if the child has health issues early in their life or sexual development issues further down the road?

Has anyone here successfully had a child while PFS’d?

If so, were there any health challenges?

Has your child successfully gone through puberty and sexual maturation?

Thank you for addressing a highly personal situation.

#2

There are several with children. It should not affect the base DNA assuming you are not on Propecia any longer.

#3

children of confirmed healthy sexually matured? Can you name the isers / point me to their posts?

And can you clarify why you feel, with certainty that long-term use of finesteride could not maim the reproductive process ?

#4

Don’t know any with kids past puberty age. Know of several recent pregnancies whilst having PFS.

Why I feel? Why I think?

Well we have no evidence to prove the PFS does in fact cause any DNA damage which is of course different from gene expression. Cocaine however, has been shown to cause abnormalities in sperm cell DNA however; (cmaj.ca/content/175/5/495.full) and there are millions upon millions of former cocaine users with fully functional children living out there.

You are taking a massive leap when you imply finasteride use even from years ago will effect the DNA of sperm cells produced today. Which is of course encoded in genes.

Now if you were on finasteride when the child was conceived that might be different, but even then I am still going to remain skeptical.

Finasteride may, over time produce mutations in DNA, but from one generation to the next this is probably unlikely. As far as inheriting PFS itself, (which is what I really think your getting at) I think this is extremely unlikely. Could a PFS victims children be vulnerable to developing PFS if they were exposed to 5 -AR inhibors? Absolutely, but PFS is not a virus or bacteria that can be directly passed on, it appears to be some sort of commonality that we share that others don’t that is intrinsic to our own genetic makeup. Do people who get PTSD pass it on directly to their children? No. Whatever PFS did to us, it has done, it shouldn’t have altered the base DNA in such a way that the same condition would be passed on genetically like a virus can be if the mother has it.

#5

If methylation of the AR is a cause of PFS…methylation can last across generations.This worries me as well.

#6

I have seen a child conceived after the father had PFS myself in person. Granted this child was only a toddler (not past puberty) but it was a male and it appeared to be having no issues at all, it seemed like a healthy baby boy.

#7

I would not have a child if i was in bad health (which i am)

Its not fair on the child to have to grow up with sick biochemistry because his parents were selfish and only thought about themselves.

To have children you need a healthy mother and father. Thanks to modern medicine this doesnt happen anymore and sick malnourished couples are forcing their bodies to have children with toxic drugs like clomid.

It is barbarism.

#8

We dont know what could happen.
But mice with androgen receptor drug induced methylation, have passed it on to the next 3 generations.
Maybe wait until the studies are out

#9

Bump for this. Looking for more answers.

#10

Sorry to dig up an old thread…

I have this week found out my girlfriend is pregnant. It’s very early days but it’s made me think about the effect this condition could have on our children, which is how I stumbled upon this thread.

A little bit of info on where I am-

I took finasterid at 18 for two years and then I seemed to feel a drop in libido. I assumed it was more because I had been with my girlfriend for a couple of years and things eventually quieten down in that department. I was so naive I had not even really considered it could be due to fin. Anywhere eventually I dawned on me it could be so i stopped taking it cold turkey, and I have kind of been the same ever since. , rather than a sudden crash. After another year or so I went to the doc for a blood test and my testosterone was low normal range , but certainly low for my age on both occasions I was tested. (Around 12 nmol). On top of this I have always been a relatively poor sleeper, but it seems to have got worse In the last few years.
The enigma is, did fin cause it to worsen my sleep and In turn my t level? The other way round? I also don’t have ED, I have slightly weaker erections as you would expect if it correlates with t levels, but many in here seem to have complete ED but normal t levels. For all I know my (relatively mild compared to most others) may have been there before I took fin. I have noticed that when I go through a period of good sleep, the hair on my leg increases, maybe i have sleep disorder as the primary cause, as there is a proven link between sleep and t levels. I should also mention we conceived the first month of trying.

Anyway… the reason for my post.

I’m not much of a scientist, but even if this condition is due to methylation/epigenetic changes, is it not impossible to pass androgen sensitivity abnormalities to a son, as they are located on the X chromosome that comes from the mother. Does anyone no anymore about this?

Cheers!

#11

Is it coincidental that a study showing if a father with pfs can pass it down to
his child hasn’t been done yet?

I mean a real study that shows amount of neurosteroids, t-level, androgens, 5ar, etc.
in offspring fathered by non pfs subjects vs. pfs subjects vs. subjects that have recovered

This study wouldn’t take more than 1 or 2 years max to complete and isn’t that difficult to do.
How do we push for this to get done through the foundation?

Its ridiculous that there isn’t a page to request studies we’d like and yet i see requests for donations. NO offence to anyone in the foundation or this forum.
But if you believe in the severity of this condition then please get us a real study
that shows the health of children.

At least do this for the sake of preventing the suffering of children.

Many of merks claims of the safety of this poison are proven false as the years go by
please someone get a proper study done to prevent further harm asap.

Theres more than enough information out there about epigenetics getting passed down
that proves how needed this study is. I hope a mod or someone that has connections
passes this onto someone that can get to work on this. Its possible to find a way
to prevent these changes from being passed on IF there is the chance of it.

If this doesn’t get addressed soon then change the name to Merkpeciahelp.com
because seriously if the object was to get this off the market and help people
this is the priority study that should’ve been done YEARS ago.

#12

My baby boy was born 100% healthy just a week ago. Completely normal genitalia and NO signs that any possible epigenetic changes in myself were passed along.

I may have passed on whatever possible genetic susceptibilities I have to him for PFS. But as of now there is no sign of that. He is perfectly healthy.

#13

I agree this would be a very important study. It’s reassuring that there haven’t been any/many abnormalities yet, but i’m afraid there’s no way to know until the childeren have gone through puberty. This happened to people who used the medication Diethylstilbestrol (DES).

#14

Congratulations and good luck. May he stay healthy (no drugs, no pills, no cigarettes :smiley:).