No they don’t. Did Prof Melcangi once mention androgen receptors as being the cause of this?
Now we have this study and rumours of increases AR levels in NUMB genital skin. How do we put it together?
Well, there is zero evidence that upregulated ARs can reduce DHT, 5aR, increase estrogen or inhibit Neurosteroid synthesis.
However, we know that inhibiting 5aR upregulates Androgen Receptors[1] AND reduces DHT, increases estrogen and inhibits neurosteroid synthesis.
Therefore the problem lies with 5aR. Occams razor and all that!