Like I have mentioned before I dont think you supplement this. Its not how it works in nature, but this is something to keep in mind in a possible dysbiosis state.
Italian researchers have proposed that vitamin K2 supplementation may be of great therapeutic value for patients diagnosed with small intestinal bacterial overgrowth (SIBO) by linking subclinical atherosclerosis to SIBO via vitamin K2-dependent mechanisms. The results of this important observational study have recently been published in the World Journal of Gastroenterology
Patients with SIBO suffer from the presence of excessive bacteria in the small intestine, and also from unintentional weight loss, nutritional deficiencies, and osteoporosis. This disease is frequently blamed for causing chronic diarrhea and malabsorption. Moreover, recent studies have highlighted that patients with SIBO have low circulating levels of vitamin K2.2 Several maladies of the gastrointestinal tract, wherein gut bacteria act in a pathogenic capacity, are associated with vascular dysfunction and increase the risk of atherosclerosis in the host.
SIBO patients presented with a higher concentration of inactive form of MGP and arterial stiffness was elevated in this group. This phenomenon was reported to correlate linearly with the levels of inactive MGP. Carotid intima-media thickness and arterial calcifications were not observed to be significantly elevated as compared to controls.
“Assessing vitamin K2 status may be particularly valid for patients with small intestinal bacterial overgrowth (SIBO), since they are more prone to subclinical atherosclerosis due to reduced MGP activation and arterial stiffening,” says Dr. Katarzyna Maresz, president of the International Science and Health Foundation. “Such early detection enables a novel therapeutic approach of supplementing patients affected by SIBO with vitamin K2, which may be very beneficial in the treatment of this intestinal dysbiosis.”
gut bacterial overgrowth linked to heart disease
Vitamin K2 intake from diet did not appear to contribute to subclinical atherosclerosis, suggesting that small intestinal dysbiosis and low bacterial vitamin synthesis were fundamental.