I hope Baylor study find the root cause of PFS.
I think AR epigenetic changes a cause.(just my thought)
But Big pharma like merck have a big power and lots of money.
I am afraid when merck give money to baylor, we still in this place.
I want to live just a normal life…!!!
Fasting can trigger epigenetic changes.
Fasting can increase AR sensitivity due to increased androgen levels as well.
If some parts of the body are inflamed in pfs status like gut!, paleo or intermittent fasting are the ways to heal symptoms linked to gut issues like depression or immun system as they are deflaming.
Detoxing esp of the liver helps building hormones, metabolizing stuff and reducing of inhibition of several pathways by certain metals as healing gut issues.
Most ppl tried to raise their testo to supraphysiological levels to desentisise AR.
Though done by docs and to be found in literature, this procedure wasn’t really successful in pfs ppl.
But decreasing androgen to low levels and increasing them to the current state could do that.
This can be done by prog or Ella cycling. As mentioned before.
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(Water)fasting will completely crash your androgens. Its just like taking a strong 5ARi like progesterone. It might have some benefits for guys with gut/immune issues yes, but in terms of sexual symptoms its actually dangerous and risky like progesterone.
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Yeah it’s impossible now for me build muscle mass and/or lose fat.
Do you know when studies are coming out?
Nobody does as I understand it, but not as long from today as it was yesterday.
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Your post makes sense in normal ppl. Not in pfs. AR are upregulated. They cannot handle androgens.
It is about cycling prog etc. for ppl with upregulated AR. Those AR cannot handle the current androgen levels. That’s why raising testo with TRT brings nothing. Ppl raising dht feel shortly better, but crash again.
PPL on prog or Ella got improvements in libido and erections.
Look at Kitsune: has good testo and supraphysiological dht levels. Result: feels worse than ever.
We have to understand what AR needs in that situation. By cycling, AR can reopen cause androgens are coming back to the current level.
Please read my post above why decreasing and I creasing of androgens is the way to go in case of upregulated and shutdown AR.
Intermittent fasting led one guy to cure.
If some issues are gut related, this is the way to go.
Maybe it is not clear what upregulated AR mean?
AR are upregulated due to decreased androgen levels esp.dht. They increase in number and sensitivity. Dht comes back and boum. Shutdown. That’s why we got in that situation.
Do you think raising dht will resentisise them?
Then just adding andractim or testogel (which is dangerous as posted here) would be the cure as some have lowish androgens. But it isn’t obviously.
Water fasting: AR can be resentisised this way. Read my comments why raising Testo brings nothing. Lots of ppl tried and failed.
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Lol I never said people should raise their DHT. I just said that prog and waterfasting are both risky for ALL pfs guys. I know it can help alot (I used prog with success), but it can also worsen people. I got fucked from milk thistle for example.
I explained that increasing androgens with hormons or prohormons can have a serious bad effect.
Very interesting your comment. You crashed taking m.th. while on fin? Right?
M.th. is a strong liver detoxifier. I guess fin could not be metabolized anymore.
Nope. Never took fin. First crashed on soy protein and calorie deficit (mild pfs), then years later crashed harder with licorice root, then months later got severe pfs from milk thistle.
MT blocks the AR. Felt the effect after 30 minutes.
Thx for the reply.
I wonder if all men crash on MT. That’s why your 23andme data would be very interesting.
I definitely agree that glucose metabolism is involved. I can no longer handle sugar (or carbs in general) the same way I could before.
Even when I have relatively small amounts of sugar/carbs, my brain fog gets drastically worse and I often times gets dry mouth. At first I thought I had diabetes, but when I got tested all tests came back negative.
I dont have this issue. It makes zero difference for my symptoms if I eat sugar or not. The only food that has impact is 5AR inhibiting food.