This is the line right here, its on the home page. Its part of the main ongoing theory.
This is increased AR expression or upregulation.
Post-Finasteride Syndrome as an Epigenetic Post-Androgen Deprivation Syndrome: A potential pathological link between Drug-Induced Androgen Receptor Overexpression and Polyglutamine Toxicity
“Persistent AR overexpression has been established in symptomatic tissue of PFS patients and is a mechanistic consequence of androgen deprivation.”
^Androgens can regulate their own expression, there are other studies that are in direct conflict with this.
Example, a consequence of androgen deprivation (meaning low serum levels or tissue) can also lead to decreased AR expression.
Androgens such as testosterone or dht can upregulate ARs.
The dutasteride study states the opposite,
Androgen serum levels return, AR expression stays decreased, become insensitive to circulating androgens.
^and that is PFS.
It would obviously be a pretty big deal to get this part right, because otherwise you are getting into the strange realm of wanting to go back on Fin or take anti-androgens. Does that make sense?
Maybe im looking at this wrong, anyone feel free to chime in.