For the record MCI, I do not respond to hormones just like the rest here, after extensive experimentation, I figured out that I respond based on how much 5ar I produce. As a side effect of 5ar enzymes I have oily skin, I have a condition that makes me extremely androgenic responsive (ironically). So I am in the same boat as you all, but I have managed to bring myself to a normal state by constantly manually managing my hormones. When my body is producing enough 5ar to reduce test to dht then I can clearly see it on my face, the more oil, the bigger my muscles, the stronger my libido, the stronger the sensations of male hormones.
When I exhaust this compromised supply, test stops working, the only thing I have found that gets my body to start regulating and producing 5ar enzymes again is hgh. I am using HGH precursors, but straight HGH. I personally KNOW this condition is blocking of the 5ar enzymes. Based on this premise I have been able to manage pfs and get my body to respond to hormones. I do not respond normally, I use DHT mainly to regulate estrogen. If I were responding properly to hormones I wouldn't be on this forum. Every single human man in the world responds to testosterone by producing 5ar and reducing it to test and experiencing the functions of the 5ar enzymes, 1, 2 (muscles, sebum, pheremones, libido, male sexual everything). The third enzyme affects ocular and neurological function, some with pfs have more 5ar suppressed and others less, the ones with neurological conditions have the third 5ar enzyme suppressed
When I stop responding to test and my 5ar enzymes run out I can see the oil stop on my face and as there is no constant reduction of test to dht the testosterone is aromatized and converted into estrogen. This in turn causes water retention and my face starts bloating, when estrogen gets extremely high I feel extreme panic and anxiety. I now know that dht will regulate estrogen, it won't solve pfs, but it is just one of the many hormones I'm using to mitigate the effects of this deeciency.
This is not an androgen receptor desensitizing as if it were, more testosterone would work, but in pfs affected men, less testosterone works, that contradicts the premise that this is a dulled receptor problem. There is in fact a way to test for pfs, go on testosterone, if after a week or a month you crash, you have pfs, because guess what? No other human male does that! I was initially able to live awesome controlling my low test (prob induced by finasteride) with hrt. Then when I took avodart I crashed and am in the same boat as all of you. By using hormones to mitigate the cascade effect of the lack of these enzymes on my hormones, I have been able to bring myself to a somewhat normal condition.
99% of you would be ecstatic to be where I am, but I lost a lot of muscle size, when my body starts producing more 5ar my body can literally double in size within a week. With my protocols I have a functional and strong libido, not like before pfs, but it works, I can get off a few times a day and usually do.
The reason pfs sufferers respond better to lower doses of test is because they have a limited number of these 5ar enzymes, the correct dose to ratio of the compromised enzymes will reduce that dose of test to dht and dht will regulate estrogen. Higher dose and it will overwhelm the compromised supply and estrogen dominance takes over. Tests will show normal dht because this is a constant process of constant reduction, dht can just sit there and is regulated by the body.
I suffered with this constant process for years with over active oily skin, I was on all kinds of drugs to control my skin from breaking out on test. I am very vain and vanity has brought me to find out many of these conclusions. This is not a theory, this is a practice I am guided by, so far I have never had effects of 5ar enzymes without the positive effects. Doctors and medical science know very little about this as there are no such conditions except inherent genetic ones where the child is born this way.
We have some 5ar function, and I know based on posts and my own experience that HGH helps, and HGH happens to regulate 5ar enzymes. Mew found a synthetic 5ar enzyme which was designed by some scientists as a possible treatment for 5ar defeciency. I am convinced after extensive research that if I inject this synthetic enzyme, it will start reducing my test to dht and I will feel 100% recovery. Do not be fooled, if all of you were on the exact hormone protocols I was on (tailored to your 5ar production) you would all be getting by like me as well.
It isn't easy though, I am on a lot of stuff, but I'm working on more practical protocols as I am still in testing phases. I am certain this synthetic enzyme is the cure, or at least the treatment. As for recovery stories, do we know if any of them have been able to respond to testosterone injections? I'm not sure. I do believe in time our bodies will recover, but how much time? Perhaps not everyone, many of the problems that are getting worse are due to androgen defeciency. Please check the pfs study done on penile tissue of pfs sufferers vs non pfs sufferers, the researchers theorized that the differences were due to androgen deprivation.
It isn't that I'm smarter than everyone else, it's that my genetics are such that I can see my reactions to these enzymes (even in the slightest). No one here tried lower doses of test till I said to, and when people started to use lower doses they responded. That isn't sufficient for me, I want to be cured, my next step is this enzyme. Why do some of us have pfs and others not? Oh I believe a lot of men have pfs, but they attribute it to age, depression, they have gone to hrt doctors and not responded to testosterone, since they never used it before, they don't know what it is supposed to do. I know of one man in particular and I never could figure out why he didn't respond to test, and then the other day I asked him if he took finasteride, guess what?
He doesn't know he has pfs, he just figured it is age and that testosterone doesn't do much for him. Why are we affected? It may be a gene that is triggered, it may have brought us to a prepubescent state of these enzymes, and eventually the gene triggers back and we go back into maturity. I'm not sure nor do I care why, I want a solution. Dht in fact doesn't work in pfs guys the way they would expect, but it does regulate estrogen and solves a lot of problems doing so, enhances libido when combined with testosterone, but hcg is required, it stimulates 5ar and it helps me. However, a massive surge of estrogen follows hcg use which then created problems I solve with dht.
This is pfs, you can say it's mh theory, but I'm working with this and so far operating on this premise successfully, I know this to be true. That fucking synthetic 5ar is the cure, I just don't know how to administer it, how much etc... I surmise though that I will find out real fast as the more I inject I'm sure the better I will feel and I will see my body reducing test to dht.
MCI, no hormones don't work on my correctly and it sucks, but using my extensive knowledge of hormones, I have managed this condition for now. I have yet to find any sort of doctor that has my knowledge of hormones, or can even follow me. It is frustrating, but there are many smart guys here who have contributed a lot of knowledge and experience. While we wait and hope others will solve this, we can ourselves and are working on it, who else is with me and will try this synthetic 5ar?
