If I switch to the Mediterranean, I won’t have breads and pastas with the exception of sourdough bread. I’d get complex carbs from lentils, sweet potato, quinoa. I’m also considering paleo like you have tried but not raw.
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Hmm… Maybe I’ll try to eat more kimchi. In terms of fasting I’ve had a similar experience to you. In the two days before I started keto, I completed a 48 hr fast. On the second day of the fast I actually felt really good and has higher libido than usual.
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I think it has to do with gut microbiome alterations.
When i was in paleo i could not stand tons of foods such as tomatoes, carrots, avocados… i thought it was because those are anti-5ar foods… now that i’m on 100% raw i do tolerate and enjoy them.
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acetic acid and then mixed with methanol, more than 80 % of microsomal proteins were removed as precipitates. This procedure inactivated the 5a-reductase activity completely. The soluble fraction, but not the precipitated fraction, contained compounds that inhibited 5a-reductase activity (determined by the enzymic assay or [3H]4-MA-binding) of rat liver microsomes.
Sephadex G-50 column chromatography of the methanol-soluble fraction showed separation of the inhibitory activity from the majority of the protein peak, which eluted in the void volume.
The inhibitory activity was also found in methylene chloride extracts of rat liver microsomes, suggesting that the inhibitorswere lipids.
We therefore tested various lipids for their ability to affect binding of [3H]4-MA to rat liver microsomes. Table 1 shows that only certain unsaturated fatty acids are inhibitory. Among the lipids we have tested, inhibitory fatty acids have 14-22 carbon chains and one to six double bonds. Presence of a double bond was required for inhibitory activity; saturated fatty acids were totally inactive. Only compounds with double bonds in the cis configuration were active at low concentrations (< 10 JM), whereas the trans isomers were inactive even at high concentrations (> 0.2 mM). The difference in the effects of cis and trans isomers of fatty acids is obvious when the following sets of fatty acids are compared: oleic acid (C18.l cis9) versus elaidic acid (C18: 1 trans-9), and linoleic acid (C18:2 cis-9,12) versus linolelaidic acid (C18:2, trans-9,12). The number and the position of the double bonds also affected the potency. For example, the inhibitory potencies of the C18 fatty acids were, in decreasing order: y-linolenic acid (cis-6,9, 12) > octadecatetraenoic acid (cis-6,9,12,15) > a-linolenic acid (cis-9,12,15) > linoleic acid (cis-9,12) > oleic acid (cis-9) > petroselinic acid (cis-6). Erucidic acid (C22: 1,cis-13) was inactive, whereas cis-4,7, 10,13,16,19-docosahexaenoic acid was a potent inhibitor. Undecylenic acid (C11:110) and nervonic acid (C24:1 cis-15) were also inactive. A free carboxyl group is important, since the methyl ester and alcohol analogues of these inhibitory unsaturated fatty acids were either inactive or only slightly active. Prostaglandin E2, F2, and I2 were also not active, whereas the A1, A2, B1,2 D2, E1 and F1 forms were somewhat active at 0.2 mm. Carotenes, retinals and retinoic acid were also inactive. Phosphatidylcholine, phosphatidyl-
ethanolamine, 3-diolein, retinol, 13-cis-retinoic acid, and 13-cis-retinol were slightly stimulatory
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Thanks for this but what does this mean in layman’s terms. Sorry I just have so much difficulty trying to process stuff.
Me too. hahaha
Tracing the articles, the description quoted by Tonster96 from wiki came from following description
Polyunsaturated fatty acids, found in vegetable oils, have been found to inhibit human and rat microsomal 5α-R activity. In this group, γ-linolenic acid is the most potent compound tested. Since 5α-R isozymes are intrinsic membrane proteins, their activity may depend on the unique environment of the lipid bilayer. Whether and how fatty acids may function as endogenous regulators of 5α-R remain unknown.(The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Faris Azzouni, * Alejandro Godoy, Yun Li, and James Mohler)
and ultimately based on following description written by T. Liang and S. Lion.
They concluded that
the inhibitory potencies (as 5α-reductase inhibitor) of the C18 fatty acids were, in decreasing order: γ-linolenic acid > octadecatetraenoic acid > α-linolenic acid > linoleic acid > oleic acid > petroselinic acid.
Erucidic acid was inactive (as 5α-reductase inhibitor), whereas docosahexaenoic acid was a potent inhibitor. Undecylenic acid and nervonic acid were also inactive (as 5α-reductase inhibitor).
based on their “rat liver microsomes” experiments.
I can not critically evaluate this research and its conclusion. Because of lack of scientific knowledge.
However, we need polyunsaturated fatty acids for our health and it is unrealistic to avoid it completely. So I wanted to know whether it is true or not that polyunsaturated fatty acids are 5ari.
If it is safe, I want to eat walnut and fish!
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Thanks for clarifying and to confirm yes they are.
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So, we should avoid walnut (α-linolenic acid) and fish (DHA) ?
Yep unfortunately as they are good for normal functioning people
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Can’t sleep at all on low fat. Tried a high fat, carnivore, keto diet but had to quit after 4 days because sleep got successively worse. Ironically i do best on a low protein fat and carbs ad libitum diet.
sorry in japanese
It may be too short to judge its effect. Of course it definitely depends on personal constitution.