Can we keep this on topic please as it seems to potentially be fairly important.
has improved??
These 2 studies are important regarding nuerotransmitters and plasticity.
PropeciaShiz – Did you print all this stuff out to take with you? Did you message Awor for his thoughs? Your appointment is on the 8th? Take detailed and copious notes, or take someone with you to take notes. Two sets of ears as the saying goes. I’m not sure how serious they are about a full blown project but it would be great news for us and of course all the guys down there.
Update. Board meeting between 7 endocrinologists. Finasteride confirmed to cause problems. Studies to be revealed next week. So far I have been tested for dht, 5ar activity and thyroid function. I am lucky enough to have frozen blood from a year ago to test the difference.At the moment it’s hang in there wait and see apporoach until further information can be released. I’m in very good hands. Though I’m not sure if my situation can be fixed, I hope for some they can get you the answers you desire. Check back on 13th August for studies.
ADMIN EDIT:
SOLICITATION DETAILS REDACTED UNTIL RESEARCH INITIATIVE HAS BEEN VERIFIED WITH THE INVOLVED DOCTORS/INSTITUTION.
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Thanks Kev, you’ll receive an email in a couple of days.
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They are looking for people who can definately be there in person or are they just collecting data for study protocol purposes at this point?
Wow! Thanks everyone for the quick replies and interest fantastic!
Hey Boston,
At the moment we are compiling a database and working on the specific trends in Hypogonadal victims.
Email will be feed out in a week or next couple of days with more information and what research is being done.
Thanks,
P.S sorry guy forgot to mention please put down what treatments you have used and please send blood work, if possible. If not will contact if required.
Does anyone happen to know the location of this compression/edema, I am assuming it would be in the exact same place in all of us since we have the same symptoms?
I think it is important to know exactly what we are dealing with here. I don’t get why there is not a harder push in this direction…the sexual symptoms are an obvious nerve problem so why does this keep getting brushed under the carpet. IMO the drug caused inflammation which has caused pelvic tissue changes. Now the drug is gone we should be focusing on the issues within the pelvis and the widespread implication of the inflammation.
Apparently there is no offered cure for PN but surely they give advice, they cant just say oh that’s it…even if they were offering surgery for god sake! Did they not recommend trying physical therapy or some obscure anti-inflammatory? Has anyone tried following the protocols on the Hard Flaccid site? There is a case log in there by a guy called Recovering, very interesting!
I’ve found another person with this problem from taking dbol (prohormone) which in no way inhibits DHT. I also found people taking ATD & Anti-aromatase end up with this after finishing the drug. This would mean that all the people taking these supplements would have above average DHT levels and estrogen levels when they cease taking the drug.
Where is the connection? I know I will get shot down for this but I personally think this is key in finding out what happened.
I know this much:
Estrogen -> activates mast cells -> irritates pudendal nerve by producing histamines -> histamines causes the veins to become leaky and control the flow of blood through the nerves -> edema builds up.
could this be Estrogen -> Edema here? I don’t know but estrogens cause edemas.
Frustrated also had a limited recovery taking histamines which would make sense here, the action of increased estrogen was blocked and since they don’t work anymore I would say the inflammation/compression of the nerve is at a completely different stage now.
Anti-estrogens would make sense here too, they would have stopped the inflammation early in it’s process and the problem would have been controlled.
nystatin and PEA sound very promising through reading other posts. how many benefitted from taking nystatin? is anyone currently pursuing this?
I appreciate your post. But your jumping to a massive conclusion there. I’m not in a position to say whether your right your wrong , but I really don’t think thats the case.
Propecia inhibits the conversion of T to DHT and we have come to learn neurosteroids and conversions to deoxcorticosterone.
Personally I believe.
DHT was supressed, Downregulating the HPTA.
Levels of estrogen increase due to DHT conversion.
Body Attempts to stablise.
Negative effect on Loop resulting in Crash.
LH levels decrease along with testosterone
IGF1 levels increase compensating for lack of LH - FSH.
IGF1 Increases to high levels, though there is a lack of proteins to bind to, so it is roaming without a home.
Androgen levels stay at low levels due to feedback loop being down regulated
extra notes
Levels of Aldosterone drop due to 5alpha reductase enzyme and Deoxcorticosterone --> aldosterone conversion.
Shrinkage due to decrease in DHT and increase in estrogen.
I don’t want to beat around the bush , i’m not a scientist and don’t have the answer. Why you think Propecia caused Pelvic inflammation is beyond me. Pudenal neuropathy caused by propecia? I don’t think. I think you’ll find it was caused by lack of androgens.
Also those who wanted an update nothing will be commencing till more australians come forward. I need 20 participants.
The reason being is we ended up with the same symptoms (sexually at least) when I never had low test levels…I did however have high DHT and E2 levels after quitting.
This numb/HF thing happened to me overnight…I couldn’t see a toxic reaction to the nerve occurring that quickly, I could however see ischemia happening…again why would this occur? Some sort of inflammation I would guess and therefore compression from the connective tissues…this is something that reacts quickly to threats.
It is well documented that estrogen causes pelvic inflammation/prostatitis. If you want to go further you could say that without anti-inflammatory androgens it could also enhance the pro-inflammatory reaction. Why did antihistamines and anti-estrogens work for some then?
So what I am saying is, lack of androgens in my case did not cause this…perhaps too much and too much estrogen. You try and work that one out…similar with the steroid guys…this was happening to them on cycle so did they suddenly have a drop in androgen levels? no they didn’t!
We are both guessing here but if people were benefiting from pelvic floor exercises and the like then im definitely pursuing it…that’s probably the only thing i’ve read that helps for these types of problems. That guy on HF got better with overnight PFD and numb penis…why can’t we?
The pudendal neuropathy is real and we all have it whether you agree with it or not.
Jeff, can you please share some links/citations of antihistamines relieving PFS sexual sides? Can you also share the same w steroid abuses who ended up with HF or like symptoms? Thanks!
Sorry but I disagree. Are you over weight cause that do it to? It’s your opinion
It wasn’t a general thing but Frustrated said he has relief from taking claritin early on, he said he went to 100% normal for a couple of weeks. It now doesn’t have an effect on his symptoms.
Recent example I found of someone taking a pro-hormone and ended up with this:
uk-muscle.co.uk/steroid-test … -help.html
I can’t find the link but two guys took Novedex XT and ended up with the same sexual side effects.
I had tension in my pelvic floor before this hit, I am sure of it.
I know it is my opinion but I am just trying to help, I can’t ignore the similarities between us and the HF guys on hardflaccid.org
You don’t know these guys history. It’s
A huge assumption, being overweight can do
The same thing. Over hearing the theories.
I don’t know pudenal neuropathy can be caused by inhibiting dht…
If your talking about gentile numbness
That can be caused by androgen deprivation. What do you think
Finasteride is a antagonist.
I didn’t have actually have anything close to a 100% recovery for any period of time, but after taking daily claritin my anorgasmia and numbness improved by a little bit - reminding me what it is like to feel an orgasm after all of these years. It did not do anything to improve erectile function and the effects disappeared within less than a week. I got the idea from the following article. I don’t think it necessarily has to do with nerve compression or inflammation - I do not have an opinion on this. My doctor had another patient who reported positive effects from Claritin and thought it could possibly be explained by a temporary reversal in a dopamine deficiency. All I know is from personal experience that it seems to have helped for a hot minute.
Jeff, a thread by a group of steroids users is just another theory. Pudenal Neuropathy caused by propecia? Really… I think people are missing the point SSRI have nothing to do with propecia yeah there are similar side effects but they both work in completely different ways. Finsateride lowers DHT by inhibiting the 5 alpha reductase enzyme, it makes perfect sense that is the reason for shrinkage. It deprives the tissue of DHT.
Why do you think mens penis’s shrink as they age reduction in testosterone = reduction in DHT.